Safety evaluation of certain food additives - ipcs inchem

FURAN-SUBSTITUTED ALIPHATIC HYDROCARBONS 503
Table 3. Results of short-term studies of toxicity with furan-substituted aliphatic hydrocarbons, alcohols, aldehydes,
ketones, carboxylic acids and related esters, sulfides, disulfides and ethers used as flavouring agents
References
NOELc /NOAELd (mg/
kg bw per day)
Route Duration
(days)
No. Flavouring agent Species; sex No. of test groupsa /
no. per groupb 1491 2-Pentylfuran Rat; M, F 1/30–46 Diet 90 25.6c,e Shellenberger (1971b,
1971c)
1495 2,3-Dimethylbenzofuran Rat; M, F 1/30 Gavage 90 0.6 c,e Long (1977a)
1497 3-(2-Furyl)acrolein Rat; M, F 3/10 Gavage 30 100 d Faber & Hosenfeld (1992)
1497 3-(2-Furyl)acrolein Rat; M, F 3/20–64 Diet 90 45 d Lough et al. (1985)
1502 2-Phenyl-3-(2-furyl)-prop-2-enal Rat; M, F 1/30 Gavage 90 0.87 c,e Long (1977b)
1503 2-Furyl methyl ketone Rat; M, F 3/20–64 Diet 90 25 d Lough et al. (1985)
1506 3-Acetyl-2,5-dimethylfuran Rat; M, F 1/10 Diet 14 10 c,e Van Miller & Weaver (1987)
1511 4-(2-Furyl)-3-buten-2-one Rat; M, F 1/10 Diet 14 30 c,e Gill & Van Miller (1987)
1514 Isobutyl 3-(2-furan)propionate Rat; M, F 3/20–64 Diet 90 875 c,e Lough et al. (1985)
1520 Furfuryl methyl ether Rat; M, F 1/10 Diet 14 27 c,e Van Miller & Weaver (1987)
Rat; M, F 3/6 Gavage 28 2d Van Otterdijk & Frieling
(2001)
1526 O-Ethyl S-(2-furylmethyl)thiocarbonate
F, female; M, male.
a Total number of test groups does not include control animals.
b Total number per test group includes both male and female animals.
c No-observed-effect level.
d No-observed-adverse-effect level.
e Study performed with either a single dose or multiple doses that had no adverse effect; the value is therefore the highest dose level tested.