Safety evaluation of certain food additives - ipcs inchem

ALKOXY-SUBSTITUTED ALLYLBENZENES 407
Table 4 (contd)
No. Flavouring agent End-point Test object Concentration Results References
Negative d Müller et al. (1994)
1789 Estragole Chromosomal aberration V79 cells 1.48–468 μg/mlc (105 –3.16 ×
103 mol/l)
Positive h Howes et al. (1990b)
1789 Estragole UDS Rat hepatocytes 0.148–7400 μg/mlc (106 –5 ×
102 mol/l)
Positive h Chan & Caldwell (1992)
1789 Estragole UDS Rat hepatocytes 14.8–148 μg/mlc (104 –103 mol/l)
1789 Estragole UDS Rat hepatocytes 148 μg/ml c (10 3 mol/l) Positive h Caldwell et al. (1992)
1789 Estragole UDS Rat hepatocytes 740 μg/ml c (5 × 10 3 mol/l) Positive Howes et al. (1990a, 1990b)
30, 60, 120 and 300 μg/plate Negatived Sekizawa & Shibamoto
(1982)
1790 Methyl eugenol Reverse mutation S. typhimurium TA98,
TA100, TA1535, TA1537
and TA1538
36 μg/plate i (0.2 μmol/plate) Negative g Dorange et al. (1977)
1790 Methyl eugenol Reverse mutation S. typhimurium TA98,
TA100, TA1535, TA1537
and TA1538
3–333 μg/plate Negatived National Toxicology
Program (2000)
1790 Methyl eugenol Reverse mutation S. typhimurium TA98,
TA100, TA1535 and
TA1537
3–333 μg/plate Negative d Mortelmans et al. (1986)
1790 Methyl eugenol Reverse mutation S. typhimurium TA98,
TA100, TA1535 and
TA1537
Negative d Schiestl et al. (1989a)
45–1069 μg/platei (0.25–6
μmol/plate)
1790 Methyl eugenol Reverse mutation S. typhimurium TA97,
TA98, TA100 and TA102