Safety evaluation of certain food additives - ipcs inchem

ALKOXY-SUBSTITUTED ALLYLBENZENES 419
Table 4 (contd)
No. Flavouring agent End-point Test object Concentration Results References
Positive f Myhr et al. (1985)
1792 Safrole Forward mutation L5178Y mouse lymphoma cells 22 and 88 μg/mlr (20 and
80 nl/ml)
Positive d Styles et al. (1985)
1792 Safrole Forward mutation L5178Y mouse lymphoma cells 6.9, 13.7, 27.4 and
54.8 μg/ml
1792 Safrole Forward mutation L5178Y mouse lymphoma cells 6.25–100 μg/ml Positive d Garner & Campbell (1985)
Negative g Oberly et al. (1985)
1792 Safrole Forward mutation L5178Y mouse lymphoma cells 1, 10, 20, 30, 40, 50, 60 and
70 μg/ml
Negative f Oberly et al. (1985)
1792 Safrole Forward mutation L5178Y mouse lymphoma cells 0.05, 0.1, 0.25, 0.5, 0.75, 1,
2.5 and 5 μg/ml
Inconclusivehh Knaap & Langebroek
(1985)
1792 Safrole Forward mutation L5178Y mouse lymphoma cells 33, 49, 66 and 82 μg/mlr (0.030, 0.045, 0.060 and
0.075 μl/ml)
1792 Safrole Forward mutation L5178Y mouse lymphoma cells 4.4–160 μg/ml Positive g,ii Jotz & Mitchell (1981)
1792 Safrole Forward mutation L5178Y mouse lymphoma cells 3.8–50 μg/ml Positive f Jotz & Mitchell (1981)
Negative g,jj Myhr & Caspary (1988)
1792 Safrole Forward mutation L5178Y mouse lymphoma cells 6.25, 12.5, 25, 50, 75 and
100 μg/ml
Positive f,jj Myhr & Caspary (1988)
1792 Safrole Forward mutation L5178Y mouse lymphoma cells 1.56, 3.13, 6.25, 12.5, 25, 50
and 100 μg/ml
Positive f,jj Myhr & Caspary (1988)
1792 Safrole Forward mutation L5178Y mouse lymphoma cells 3.13, 6.25, 12.5, 25, 50 and
75 μg/ml