Safety evaluation of certain food additives - ipcs inchem

410 ALKOXY-SUBSTITUTED ALLYLBENZENES
Table 4 (contd)
No. Flavouring agent End-point Test object Concentration Results References
32 μg/plate o (0.2 μmol/plate) Negative g Dorange et al. (1977)
1792 Safrole Reverse mutation S. typhimurium TA98, TA100,
TA1535, TA1537 and TA1538
Negative g Green & Savage (1978)
1000–5000 μg/plate (1–5 mg/
plate)
1792 Safrole Reverse mutation S. typhimurium TA1530,
TA1531, TA1532 and TA1964
Positive f,q Green & Savage (1978)
400 and 4000 μg/mlo (0.0025 and
0.025 mol/l)
1792 Safrole Reverse mutation S. typhimurium TA1530,
TA1531, TA1532 and TA1964
Not provided Positive d Green (1975)
1792 Safrole Reverse mutation S. typhimurium TA1530 and
TA1532
Negative d Eder et al. (1980)
1792 Safrole Reverse mutation S. typhimurium TA100 1.65–165 μg/mlr (0.0015–0.15
μl/ml)
Negative d Eder et al. (1982a)
1792 Safrole Reverse mutation S. typhimurium TA100 1.65–165 μg/mlr (0.0015–0.15
μl/ml)
3.2, 10, 32 and 100 μg/plate Negative d Baker & Bonin (1985)
1792 Safrole Reverse mutation S. typhimurium TA97, TA98,
TA100 and TA102
Negative d Eder et al. (1982b)
1792 Safrole Reverse mutation S. typhimurium TA100 0.0016–0.16 μg/mlr (0.0015–0.15
μl/ml)
5–250 μg/ml Negative Wislocki et al. (1977)
1792 Safrole Reverse mutation S. typhimurium TA100 and
TA1535
4, 20, 100, 500 and 2500 μg/plate Positive Anderson & Styles (1978)
1792 Safrole Reverse mutation S. typhimurium TA98, TA100,
TA1535 and TA1538