Safety evaluation of certain food additives - ipcs inchem

ALKOXY-SUBSTITUTED ALLYLBENZENES 427
Table 4 (contd)
No. Flavouring agent End-point Test object Concentration Results References
Simmon et al. (1979)
869 and 5500 mg/kg bwuu Positiveww Negativexx S. typhimurium TA1530
and TA1538 in mouse
1792 Safrole Host-mediated reverse
mutation
869 mg/kg bw uu Negative Simmon et al. (1979)
S. cerevisiae D3 in
mouse
1792 Safrole Host-mediated reverse
mutation
1792 Safrole SCE Mouse 0.1–20 mg/kg bw Negative yy Paika et al. (1981)
Positive Sharma et al. (1982)
1792 Safrole Chromosomal aberration Rat 658, 888 and 1097 mg/kg
bwr (0.6, 0.8 and
1.0 ml/kg)
1792 Safrole UDS Rat 200 and 1000 mg/kg bw qq Negative Mirsalis et al. (1982)
1792 Safrole UDS Mouse 640 mg/kg bwzz Positive Friedman & Staub
(1976)
1792 Safrole UDS Mouse Up to 50% of LD50 value Negative Robertson (1978)
Positive Uno et al. (1994)
1792 Safrole UDS Rat 500 and 1000 mg/kg
bwaaa Positive Ohtsuka et al. (1998)
1792 Safrole UDS Rat 250, 500 and 1000 mg/kg
bw
Negative Gocke et al. (1981)
1792 Safrole Micronucleus induction Mouse 55, 110 and 220 mg/kg
bwbbb Negative Katz et al. (1981)
1792 Safrole Micronucleus induction Mouse 0.36 mg/kg bwr (0.33 ml/
kg bw)