Safety evaluation of certain food additives - ipcs inchem

320 ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS
Table 5 (contd)
No. Flavouring agent End-point Test object Concentration Results Reference
0.005–25 mg/plate Negative Schweikl et al. (1994)
Reverse mutation S. typhimurium TA97a, TA98,
TA100, TA102 and TA104
1834 Methyl 2-methyl-
2-propenoate
100–2000 μg/plate, ±S9 Negative a Emmert et al. (2006)
Reverse mutation S. typhimurium
YG7108pin3ERb5
1834 Methyl 2-methyl-
2-propenoate
Weakly positive h Poss et al. (1979)
Forward mutation S. typhimurium TM677 10, 50 or 100 mmol/l,
±S9 (~1000, 5000 and
10 000 μg/mld )
1834 Methyl 2-methyl-
2-propenoate
Weakly positiveh Haskell Laboratory
(1989)
Forward mutation S. typhimurium TM677 25 or 50 mmol/l (~2500 and
5000 μg/mld )
1834 Methyl 2-methyl-
2-propenoate
Positiveh Rohm & Haas Co.
(1985)
100 or 300 nl/ml (93.6 and
281 μg/mlb )
Forward mutation L5178Y mouse lymphoma
cells
1834 Methyl 2-methyl-
2-propenoate
5 mmol/l (~500 μg/ml d ) Positive i Amtower et al. (1986)
Forward mutation L5178Y mouse lymphoma
cells
1834 Methyl 2-methyl-
2-propenoate
National Toxicology
Program (1986)
Positivei ;
ambiguousj 0.125–1 μl/ml (117–936
μg/mlb )
Forward mutation L5178Y mouse lymphoma
cells
1834 Methyl 2-methyl-
2-propenoate
Up to 3000 μg/ml, S9 Positive k Moore et al. (1988)
Forward mutation L5178Y mouse lymphoma
cells
1834 Methyl 2-methyl-
2-propenoate
1000–3000 μg/ml, S9 Weakly positive k Doerr et al. (1989)
Forward mutation L5178Y mouse lymphoma
cells
1834 Methyl 2-methyl-
2-propenoate
Positive f Myhr et al. (1990)
125–2000 nl/ml, ±S9
(117–1872 μg/mlb )
Forward mutation L5178Y mouse lymphoma
cells
1834 Methyl 2-methyl-
2-propenoate