Safety evaluation of certain food additives - ipcs inchem

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ANNEX 4 621 3. FLAVOURING AGENTS 3.1 Flavourings evaluated by the Procedure for the Safety Evaluation of Flavouring Agents A. Aliphatic branched-chain saturated and unsaturated alcohols, aldehydes, acids and related esters Flavouring agent No. Specifications a Conclusions based on current estimated intake Structural class I Ethyl (E)-2-methyl-2-pentenoate 1815 N No safety concern 2-Methylbutyl 3-methyl-2-butenoate 1816 N No safety concern (±)(E,Z)-5-(2,2- Dimethylcyclopropyl)-3-methyl- 2-pentenal 1817 N No safety concern (E,Z)-4-Methylpent-2-enoic acid 1818 N No safety concern (±)-4-Ethyloctanal 1819 N No safety concern (E)-Geranyl 2-methylbutyrate 1820 N No safety concern (E)-Geranyl valerate 1821 N No safety concern (E)-Geranyl tiglate 1822 N No safety concern (E)-Citronellyl 2-methylbut-2-enoate 1823 N No safety concern (E)-Ethyl tiglate 1824 N No safety concern (E,Z)-Geranic acid 1825 N No safety concern Prenyl formate 1826 N No safety concern Prenyl acetate 1827 N No safety concern Prenyl isobutyrate 1828 N No safety concern Prenyl caproate 1829 N No safety concern (±)-Dihydrofarnesol 1830 N No safety concern (E,Z)-3,7,11- Trimethyldodeca-2,6,10-trienyl acetate 1831 N No safety concern (E,Z)-Phytol 1832 N No safety concern (E,Z)-Phytyl acetate Structural class II 1833 N No safety concern Methyl 2-methyl-2-propenoate 1834 N No safety concern a N, new specifications prepared. B. Aliphatic linear ,-unsaturated aldehydes, acids and related alcohols, acetals and esters Flavouring agent No. Specifications a Conclusions based on current estimated intake Structural class I (Z)-2-Penten-1-ol 1793 N No safety concern (E)-2-Decen-1-ol 1794 N No safety concern (Z)-Pent-2-enyl hexanoate 1795 N No safety concern
622 ANNEX 4 Flavouring agent No. Specifications a Conclusions based on current estimated intake (E)-2-Hexenyl octanoate 1796 N No safety concern trans-2-Hexenyl 2-methylbutyrate 1797 N No safety concern Hept-trans-2-en-1-yl acetate 1798 N No safety concern (E,Z)-Hept-2-en-1-yl isovalerate 1799 N No safety concern trans-2-Hexenal glyceryl acetal 1800 N No safety concern trans-2-Hexenal propylene glycol acetal 1801 N No safety concern cis- and trans-1-Methoxy-1-decene 1802 N No safety concern (E)-Tetradec-2-enal 1803 N No safety concern (E)-2-Pentenoic acid 1804 N No safety concern (E)-2-Octenoic acid 1805 N No safety concern Ethyl trans-2-butenoate 1806 N No safety concern Hexyl 2-butenoate 1807 N No safety concern Ethyl trans-2-hexenoate 1808 N No safety concern (E,Z)-Methyl 2-hexenoate 1809 N No safety concern Hexyl trans-2-hexenoate 1810 N No safety concern Methyl trans-2-octenoate 1811 N No safety concern Ethyl trans-2-octenoate 1812 N No safety concern (E,Z)-Methyl 2-nonenoate 1813 N No safety concern Ethyl trans-2-decenoate 1814 N No safety concern a N, new specifications prepared. C. Aliphatic secondary alcohols, ketones and related esters Flavouring agent No. Specifications a Conclusions based on current estimated intake Structural class I Isopropenyl acetate 1835 N No safety concern 1-Octen-3-yl acetate 1836 N No safety concern 1-Octen-3-yl butyrate 1837 N No safety concern 6-Methyl-5-hepten-2-yl acetate 1838 N No safety concern 3-(Hydroxymethyl)-2-octanone 1839 N No safety concern (±)-[R-(E)]-5-Isopropyl- 8-methylnona-6,8-dien-2-one 1840 N No safety concern (±)-cis- and trans-4,8-Dimethyl-3, 7-nonadien-2-ol 1841 N No safety concern 2,4-Dimethyl-4-nonanol Structural class II 1850 N No safety concern (±)-1-Hepten-3-ol 1842 N No safety concern (E,Z)-4-Octen-3-one 1843 N No safety concern (E)-2-Nonen-4-one 1844 N No safety concern (E)-5-Nonen-2-one 1845 N No safety concern (Z)-3-Hexenyl 2-oxopropionate 1846 N No safety concern (±)-cis- and trans-4,8-Dimethyl-3, 7-nonadien-2-yl acetate 1847 N No safety concern
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WHO FOOD ADDITIVES SERIES: 60 Safet
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CONTENTS Preface ..................
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PREFACE The monographs contained in
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ASPARAGINASE FROM ASPERGILLUS NIGER
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16 CALCIUM LIGNOSULFONATE (40-65) 1
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18 CALCIUM LIGNOSULFONATE (40-65) ~
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20 CALCIUM LIGNOSULFONATE (40-65) A
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22 CALCIUM LIGNOSULFONATE (40-65) c
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24 CALCIUM LIGNOSULFONATE (40-65) T
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28 CALCIUM LIGNOSULFONATE (40-65) i
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ETHYL LAUROYL ARGINATE First draft
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ETHYL LAUROYL ARGINATE 41 and Devel
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ETHYL LAUROYL ARGINATE 43 lauroyl a
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ETHYL LAUROYL ARGINATE 45 arginine.
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ETHYL LAUROYL ARGINATE 47 resulting
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ETHYL LAUROYL ARGINATE 49 Table 4.
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ETHYL LAUROYL ARGINATE 51 weight ch
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ETHYL LAUROYL ARGINATE 53 stomach l
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ETHYL LAUROYL ARGINATE 55 fibrosis
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ETHYL LAUROYL ARGINATE 57 Table 5 (
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ETHYL LAUROYL ARGINATE 59 first 4 d
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ETHYL LAUROYL ARGINATE 61 The gener
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ETHYL LAUROYL ARGINATE 63 treatment
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ETHYL LAUROYL ARGINATE 65 gestation
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ETHYL LAUROYL ARGINATE 67 Body weig
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ETHYL LAUROYL ARGINATE 69 Table 6.
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ETHYL LAUROYL ARGINATE 77 About 99%
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ETHYL LAUROYL ARGINATE 79 concentra
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ETHYL LAUROYL ARGINATE 81 theoretic
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ETHYL LAUROYL ARGINATE 83 Huntingdo
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PAPRIKA EXTRACT First draft prepare
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PAPRIKA EXTRACT 87 of capsanthin ra
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PAPRIKA EXTRACT 89 biochemical para
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PAPRIKA EXTRACT 91 Table 1. Sales o
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PAPRIKA EXTRACT 93 Table 2. Estimat
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PAPRIKA EXTRACT 95 The European Sci
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PAPRIKA EXTRACT 97 The potential di
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PAPRIKA EXTRACT 99 Hornero-Mendez,
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PAPRIKA EXTRACT 101 Appendix 1. Res
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PAPRIKA EXTRACT 103 Appendix 1. (co
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PAPRIKA EXTRACT 105 Appendix 1. (co
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108 PHOSPHOLIPASE C EXPRESSED IN PI
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PHYTOSTEROLS, PHYTOSTANOLS AND THEI
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166 POLYDIMETHYLSILOXANE (addendum)
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STEVIOL GLYCOSIDES (addendum) First
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STEVIOL GLYCOSIDES (addendum) 185 r
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STEVIOL GLYCOSIDES (addendum) 187 c
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STEVIOL GLYCOSIDES (addendum) 189 a
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STEVIOL GLYCOSIDES (addendum) 191 N
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STEVIOL GLYCOSIDES (addendum) 193 2
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STEVIOL GLYCOSIDES (addendum) 195 T
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STEVIOL GLYCOSIDES (addendum) 197 a
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STEVIOL GLYCOSIDES (addendum) 199 r
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STEVIOL GLYCOSIDES (addendum) 201 l
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STEVIOL GLYCOSIDES (addendum) 203 g
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STEVIOL GLYCOSIDES (addendum) 209 t
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STEVIOL GLYCOSIDES (addendum) 211 t
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STEVIOL GLYCOSIDES (addendum) 213 s
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STEVIOL GLYCOSIDES (addendum) 215 C
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STEVIOL GLYCOSIDES (addendum) 217 L
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STEVIOL GLYCOSIDES (addendum) 219 W
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222 SULFITES: ASSESSMENT OF DIETARY
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SAFETY EVALUATIONS OF GROUPS OF REL
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264 INTRODUCTION Figure 1. Procedur
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DIETARY EXPOSURE ASSESSMENT OF FLAV
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292 ALIPHATIC BRANCHED-CHAIN SATURA
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332 ALIPHATIC LINEAR ,-UNSATURATED
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ALKOXY-SUBSTITUTED ALLYLBENZENES PR
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FURAN-SUBSTITUTED ALIPHATIC HYDROCA
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HYDROXY- AND ALKOXY-SUBSTITUTED BEN
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MISCELLANEOUS NITROGEN-CONTAINING S
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Page 578 and 579: MISCELLANEOUS NITROGEN-CONTAINING S
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Page 587 and 588: 580 SUBSTANCES STRUCTURALLY RELATED
Page 602: ANNEXES
Page 605 and 606: 598 ANNEX 1 10. Specifications for
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Page 615 and 616: 608 ANNEX 1 188. Safety evaluation
Page 617 and 618: 610 ANNEX 2 ECG electrocardiogram E
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Page 624 and 625: ANNEX 4 ACCEPTABLE DAILY INTAKES, O
Page 626 and 627: ANNEX 4 619 Food additive Specifica
Page 630 and 631: ANNEX 4 623 Flavouring agent No. Sp
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Page 638 and 639: ANNEX 5 SUMMARY OF THE SAFETY EVALU
Page 640 and 641: ANNEX 5 633 Secondary components Co
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