Safety evaluation of certain food additives - ipcs inchem

426 ALKOXY-SUBSTITUTED ALLYLBENZENES
Table 4 (contd)
No. Flavouring agent End-point Test object Concentration Results References
D. melanogaster 100 and 200 ppmss Negative Valencia & Houtchens
(1981)
1792 Safrole Sex-linked recessive
lethal mutation
D. melanogaster 0.5, 1 and 5 mmol/l rr Negative Fujikawa et al. (1985)
1792 Safrole Sex-linked recessive
lethal mutation
Marginally positive Würgler et al. (1985)
D. melanogaster 0.34, 0.68 and 6.76
mmol/l
1792 Safrole Sex-linked recessive
lethal mutation
D. melanogaster 0.5 mmol/l Positive Vogel (1985)
1792 Safrole Sex-linked recessive
lethal mutation
D. melanogaster 75 ppm Negative Zimmering et al. (1989)
1792 Safrole Sex-linked recessive
lethal mutation
D. melanogaster 0.5 and 1 mmol/ltt Positive Batiste-Alentorn et al.
(1994)
1792 Safrole Sex-linked recessive
lethal mutation
D. melanogaster 0.1, 0.5 and 1 mmol/l Negative Batiste-Alentorn et al.
(1995)
1792 Safrole Sex-linked recessive
lethal mutation
D. melanogaster 0.1, 0.25 and 0.5 mmol/l tt Negative Consuegra et al. (1996)
1792 Safrole Sex-linked recessive
lethal mutation
200 mg/kg bw uu Positive vv Green & Savage (1978)
S. typhimurium TA1534,
TA1950, TA1951 and
TA1952 in mouse
1792 Safrole Host-mediated
reverse mutation
Not provided Positive Green (1975)
S. typhimurium TA1950
and TA1952 in mouse
1792 Safrole Host-mediated
reverse mutation