Safety evaluation of certain food additives - ipcs inchem

FURAN-SUBSTITUTED ALIPHATIC HYDROCARBONS 515
Table 4 (contd)
No. Flavouring agent End-point Test system Concentration/ dose Results References
Not specified Slightly positive j Eder et al. (1993)
1503 2-Furyl methyl ketone DNA damage E. coli PQ37 (SOS
chromotest)
Shinohara et al.
(1986)
Negative/
positiveb,l 550, 5500 or
55 000 μg/disc
1503 2-Furyl methyl ketone DNA damage B. subtilis H17 (rec+)
and M45 (rec)
Positive b,m,n Stich et al. (1981)
CHO cells 0–112.6 mmol/l
(0–13 220 μg/ml) j
1503 2-Furyl methyl ketone Chromosomal
aberration
Negative Durward (2007a)
1503 2-Furyl methyl ketone UDS Human hepatocytes 2.19, 4.38, 8.75,
17.5, 35, 70, 140 or
280 μg/ml
Negativeb,c,o Mortelmans et al.
(1986)
33, 100, 333, 1000,
2166 or 3333 μg/
plate
1511 4-(2-Furyl)-3-buten-2-one Reverse mutation S. typhimurium TA98,
TA100, TA1535 and
TA1537
Up to 3600 μg/plate Negative b Wild et al. (1983)
1513 Ethyl 3-(2-furyl)propanoate Reverse mutation S. typhimurium TA98,
TA100, TA1535, TA1537
and TA1538
Negativeb,p Verspeek-Rip
(2000)
33, 100, 333, 1000 or
3330 μg/plate
Reverse mutation S. typhimurium TA98,
TA100, TA1535 and
TA1537
1526 O-Ethyl-S-(2-furylmethyl)thiocarbonate
Negativeb,q Verspeek-Rip
(2000)
Reverse mutation E. coli WP2uvrA 33, 100, 333, 1000 or
3330 μg/plate
1526 O-Ethyl-S-(2-furylmethyl)thiocarbonate
Negative b,r Meerts (2000)
150, 300 or
350 μg/ml
Human peripheral
lymphocytes
Chromosomal
aberration
1526 O-Ethyl-S-(2-furylmethyl)thiocarbonate