Safety evaluation of certain food additives - ipcs inchem

412 ALKOXY-SUBSTITUTED ALLYLBENZENES
Table 4 (contd)
No. Flavouring agent End-point Test object Concentration Results References
Negative v Matsushima et al. (1985)
1, 2.5, 5, 10 , 20, 25, 50, 100,
200, 500, 1000, 2000 and 5000
μg/plateu 1792 Safrole Reverse mutation S. typhimurium TA97, TA98,
TA100 and TA102
Negative d MacDonald (1981)
10, 50, 100, 150, 200 and 300
μg/plate
1792 Safrole Reverse mutation S. typhimurium TA98, TA100
and TA1537
1–500 μg/plate Negative d Garner et al. (1981)
1792 Safrole Reverse mutation S. typhimurium TA98, TA100,
TA1535 and TA1537
0–2500 μg/plate Positive Trueman (1981)
1792 Safrole Reverse mutation S. typhimurium TA98, TA100,
TA1535, TA1537 and TA1538
Negative d Brooks & Dean (1981)
0.2, 2, 20, 200 and 2000 μg/
plate
1792 Safrole Reverse mutation S. typhimurium TA92, TA98,
TA100, TA1535, TA1537 and
TA1538
Up to 10 000 μg/ml (10 mg/ml) Negative d Baker & Bonin (1981)
1792 Safrole Reverse mutation S. typhimurium TA98, TA100,
TA1535, TA1537 and TA1538
Negative d Rowland & Severn (1981)
0.1, 1, 10, 100, 500 and 2000
μg/plate
1792 Safrole Reverse mutation S. typhimurium TA98, TA100,
TA1535, TA1537 and TA1538
Equivocal w,x Simmon & Shepherd (1981)
0.5, 10, 50, 100, 500, 1000 and
2500 μg/plate
1792 Safrole Reverse mutation S. typhimurium TA98, TA100,
TA1535, TA1537 and TA1538