Safety evaluation of certain food additives - ipcs inchem

ETHYL LAUROYL ARGINATE 47
resulting in urea and carbon dioxide. The high level of retention of radioactivity in
the carcass up to 5 days after dosing was concluded to be due to the formation of
other radiolabelled amino acids of the urea cycle, which would be subsequently
incorporated into endogenous products (Huntingdon Life Sciences Ltd, 1998g).
Six male rats were administered an oral dose of ethyl lauroyl arginate (purity,
93.2% ethyl-N -lauroyl-L-arginate HCl) at 200 mg/kg bw in a study conducted in
compliance with GLP and OECD guidelines. Arginine accounted for 48% of the total
radioactivity in the plasma, with lesser amounts of ornithine (7.7%), ethyl lauroyl
arginate (