Safety evaluation of certain food additives - ipcs inchem

518 FURAN-SUBSTITUTED ALIPHATIC HYDROCARBONS
Table 4 (contd)
x Two experimental protocols were utilized. In one experiment, animals received single oral dose administrations of the test compound. In the other
experiment, the test compound was orally administered once per day at the same concentrations as in the single-dose study for 5 consecutive days
with 24-h intervals between doses.
y No effects observed at 20 mg/kg bw dose level and only mild, but significant (P < 0.05) effects seen at higher concentrations in bone marrow cells.
z Chromosomal aberrations were observed in the presence of significant mitodepression.
aa A single statistically significant occurrence of increased chromosomal aberrations observed 3 weeks following a single dose administration in the
60 mg/kg bw test group; statistically significant increases in polyploidy and XY univalents observed at weeks 3 and 4 at 60 mg/kg bw in multipledose-treated
rats.
bb Single dose administered by gavage.