Safety evaluation of certain food additives - ipcs inchem

144 PHYTOSTEROLS, PHYTOSTANOLS AND THEIR ESTERS
Table 6 (contd)
Food additive Study population Food item Daily intake a Study duration Observations Reference
Hansel et al. (2007)
6 weeks Decrease in absolute
-carotene plasma
levels, but not in carotene
levels
adjusted to LDL
Fermented milk 1.6 g phytosterols/
day
Phytosterol esters 191 hypercholesterolaemic
subjects
Gonçalves et al.
(2007)
Milk 2 g phytosterols/day 30 days No significant
difference between
groups in -carotene
plasma levels
Phytosterols 22 healthy volunteers/34
hypercholesterolaemic
subjects
Plana et al. (2008)
42 days No significant
difference between
groups in -carotene
plasma levels
Fermented milk 1.6 g phytosterols/
day
Phytosterol esters 83 hypercholesterolaemic
subjects
a Free phytosterol or phytostanol equivalents.