Safety evaluation of certain food additives - ipcs inchem

318 ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS
Table 5. Results of studies of genotoxicity in vitro and in vivo with aliphatic branched-chain saturated and unsaturated
alcohols, aldehydes, acids and related esters
No. Flavouring agent End-point Test object Concentration Results Reference
In vitro
0.31–5000 μg/plate, ±S9 Negative a Kajiura (1997b)
1830 (±)-Dihydrofarnesol Reverse mutation Salmonella typhimurium TA98,
TA100, TA1535 and TA1537
1830 (±)-Dihydrofarnesol Reverse mutation Escherichia coli WP2uvrA 0.31–5000 μg/plate, ±S9 Negative a Kajiura (1997b)
10 mg/plate Negative a DuPont (1975)
Reverse mutation S. typhimurium TA1535,
TA1537 and TA1538
1834 Methyl 2-methyl-
2-propenoate
4–2500 μg/plate Negative a ICI (1976a)
Reverse mutation S. typhimurium TA98, TA100,
TA1535 and TA1538
1834 Methyl 2-methyl-
2-propenoate
Negative a DuPont (1979a)
0.08–2.5% (0.75–23.4
mg/mlb )
Reverse mutation S. typhimurium TA98, TA100
and TA1537
1834 Methyl 2-methyl-
2-propenoate
Weakly positive c DuPont (1979a)
Reverse mutation S. typhimurium TA1535 0.08–2.5% (0.75–23.4
mg/mlb )
1834 Methyl 2-methyl-
2-propenoate
25 mmol/l (~2500 μg/ml d ) Weakly positive e DuPont (1979a)
Reverse mutation S. typhimurium TA100
(suspension assay)
1834 Methyl 2-methyl-
2-propenoate
Negative a DuPont (1979b)
1000, 2500, 5000, 7500
or 10 000 μg/plate
Reverse mutation S. typhimurium TA98, TA100,
TA1535 and TA1537
1834 Methyl 2-methyl-
2-propenoate
Weakly positive f DuPont (1979b)
10, 25 or 50 mmol/l
(~1000, 2500 and
5000 μg/mld )
Reverse mutation S. typhimurium TA100 (liquid
suspension assay)
1834 Methyl 2-methyl-
2-propenoate