Safety evaluation of certain food additives - ipcs inchem

526 FURAN-SUBSTITUTED ALIPHATIC HYDROCARBONS
4. EVALUATION
The Committee concluded that the Procedure for the Safety Evaluation of
Flavouring Agents could not be applied to this group because of the unresolved
toxicological concerns. Studies that would assist in the safety evaluation include
investigations of the influence of the nature and position of ring substitution on
metabolism and on covalent binding to macromolecules. Depending on the findings,
additional studies might include assays related to the mutagenic and carcinogenic
potential of representative members of this group.
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