Safety evaluation of certain food additives - ipcs inchem

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ANNEX 4 625 Flavouring agent JECFA No. Specifications a 3-[(2-Methyl-3-furyl)thio]-2-butanone 1525 S O-Ethyl S-(2-furylmethyl)thiocarbonate 1526 S a S, specifications maintained. The specifications monographs will include a statement that the safety evaluation has not been completed. G. Hydroxy- and alkoxy-substituted benzyl derivatives Flavouring agent No. Specifications a Conclusions based on current estimated intake Structural class I 4-Hydroxy-3,5-dimethoxy benzaldehyde 1878 N No safety concern Vanillin 3-(l-menthoxy)propane-1,2diol acetal 1879 N No safety concern Sodium 4-methoxy benzoyloxyacetate 1880 N No safety concern Vanillin propylene glycol acetal 1882 N No safety concern 4-Methoxybenzoyloxyacetic acid Structural class III 1883 N No safety concern Divanillin 1881 N No safety concern a N, new specifications prepared. H. Miscellaneous nitrogen-containing substances Flavouring agent No. Specifications a Conclusions based on current estimated intake Structural class II Methyl isothiocyanate 1884 N No safety concern Ethyl isothiocyanate 1885 N No safety concern Isobutyl isothiocyanate 1886 N No safety concern Isoamyl isothiocyanate 1887 N No safety concern Isopropyl isothiocyanate 1888 N No safety concern 3-Butenyl isothiocyanate 1889 N No safety concern 2-Butyl isothiocyanate 1890 N No safety concern 4-(Methylthio)butyl isothiocyanate 1892 N No safety concern 4-Pentenyl isothiocyanate 1893 N No safety concern 5-Hexenyl isothiocyanate 1894 N No safety concern 5-(Methylthio)pentyl isothiocyanate 1896 N No safety concern 6-(Methylthio)hexyl isothiocyanate 1897 N No safety concern Structural class III Amyl isothiocyanate 1891 N No safety concern Hexyl isothiocyanate 1895 N No safety concern a N, new specifications prepared.
626 ANNEX 4 I. Monocyclic and bicyclic secondary alcohols, ketones and related esters Flavouring agent No. Specifications a Conclusions based on current estimated intake Structural class I Dehydronootkatone 1862 N No safety concern Isobornyl isobutyrate 1863 N No safety concern l-Bornyl acetate 1864 N No safety concern Thujyl alcohol 1865 N No safety concern Structural class II Vetiverol 1866 N No safety concern Vetiveryl acetate 1867 N No safety concern 3-Pinanone 1868 N No safety concern Isobornyl 2-methylbutyrate 1869 N No safety concern Verbenone 1870 N No safety concern a N, new specifications prepared. J. Substances structurally related to menthol Flavouring agent No. Specifications a Conclusions based on current estimated intake Structural class I Menthyl valerate 1852 N No safety concern 2-(l-Menthoxy)ethanol 1853 N No safety concern l-Menthyl acetoacetate 1854 N No safety concern l-Menthyl (R,S)-3-hydroxybutyrate 1855 N No safety concern 8-p-Menthene-1,2-diol Structural class II 1860 N No safety concern l-Piperitone 1856 N No safety concern 2,6,6-Trimethylcyclohex-2-ene- 1,4-dione 1857 N No safety concern Menthyl pyrrolidone carboxylate 1858 N No safety concern 3,9-Dimethyl-6-(1-methylethyl)- 1,4-dioxaspiro[4.5]decan-2-one 1859 N No safety concern d-2,8-p-Menthadien-1-ol 1861 N No safety concern a N, new specifications prepared. 3.2 Re-evaluation of safety of certain flavourings At the fifty-ninth, sixty-first, sixty-third and sixty-fifth meetings of the Committee (Annex 1, references 160, 166, 173 and 178), only “anticipated” annual volumes of productions were provided for some flavouring agents and used in the MSDI calculation. These volumes were used for expedience in completing a safety evaluation, but the conclusions of the Committee were made conditional pending the submission of actual poundage data.
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WHO FOOD ADDITIVES SERIES: 60 Safet
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CONTENTS Preface ..................
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PREFACE The monographs contained in
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ASPARAGINASE FROM ASPERGILLUS NIGER
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16 CALCIUM LIGNOSULFONATE (40-65) 1
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18 CALCIUM LIGNOSULFONATE (40-65) ~
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20 CALCIUM LIGNOSULFONATE (40-65) A
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22 CALCIUM LIGNOSULFONATE (40-65) c
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24 CALCIUM LIGNOSULFONATE (40-65) T
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28 CALCIUM LIGNOSULFONATE (40-65) i
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ETHYL LAUROYL ARGINATE First draft
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ETHYL LAUROYL ARGINATE 41 and Devel
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ETHYL LAUROYL ARGINATE 43 lauroyl a
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ETHYL LAUROYL ARGINATE 45 arginine.
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ETHYL LAUROYL ARGINATE 47 resulting
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ETHYL LAUROYL ARGINATE 49 Table 4.
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ETHYL LAUROYL ARGINATE 51 weight ch
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ETHYL LAUROYL ARGINATE 53 stomach l
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ETHYL LAUROYL ARGINATE 55 fibrosis
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ETHYL LAUROYL ARGINATE 57 Table 5 (
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ETHYL LAUROYL ARGINATE 59 first 4 d
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ETHYL LAUROYL ARGINATE 61 The gener
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ETHYL LAUROYL ARGINATE 63 treatment
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ETHYL LAUROYL ARGINATE 65 gestation
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ETHYL LAUROYL ARGINATE 67 Body weig
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ETHYL LAUROYL ARGINATE 69 Table 6.
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ETHYL LAUROYL ARGINATE 77 About 99%
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ETHYL LAUROYL ARGINATE 79 concentra
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ETHYL LAUROYL ARGINATE 81 theoretic
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ETHYL LAUROYL ARGINATE 83 Huntingdo
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PAPRIKA EXTRACT First draft prepare
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PAPRIKA EXTRACT 87 of capsanthin ra
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PAPRIKA EXTRACT 89 biochemical para
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PAPRIKA EXTRACT 91 Table 1. Sales o
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PAPRIKA EXTRACT 93 Table 2. Estimat
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PAPRIKA EXTRACT 95 The European Sci
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PAPRIKA EXTRACT 97 The potential di
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PAPRIKA EXTRACT 99 Hornero-Mendez,
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PAPRIKA EXTRACT 101 Appendix 1. Res
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PAPRIKA EXTRACT 103 Appendix 1. (co
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PAPRIKA EXTRACT 105 Appendix 1. (co
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108 PHOSPHOLIPASE C EXPRESSED IN PI
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PHYTOSTEROLS, PHYTOSTANOLS AND THEI
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166 POLYDIMETHYLSILOXANE (addendum)
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STEVIOL GLYCOSIDES (addendum) First
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STEVIOL GLYCOSIDES (addendum) 185 r
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STEVIOL GLYCOSIDES (addendum) 187 c
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STEVIOL GLYCOSIDES (addendum) 189 a
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STEVIOL GLYCOSIDES (addendum) 191 N
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STEVIOL GLYCOSIDES (addendum) 193 2
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STEVIOL GLYCOSIDES (addendum) 195 T
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STEVIOL GLYCOSIDES (addendum) 197 a
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STEVIOL GLYCOSIDES (addendum) 199 r
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STEVIOL GLYCOSIDES (addendum) 201 l
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STEVIOL GLYCOSIDES (addendum) 203 g
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STEVIOL GLYCOSIDES (addendum) 209 t
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STEVIOL GLYCOSIDES (addendum) 211 t
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STEVIOL GLYCOSIDES (addendum) 213 s
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STEVIOL GLYCOSIDES (addendum) 215 C
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STEVIOL GLYCOSIDES (addendum) 217 L
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STEVIOL GLYCOSIDES (addendum) 219 W
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222 SULFITES: ASSESSMENT OF DIETARY
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SAFETY EVALUATIONS OF GROUPS OF REL
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264 INTRODUCTION Figure 1. Procedur
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DIETARY EXPOSURE ASSESSMENT OF FLAV
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292 ALIPHATIC BRANCHED-CHAIN SATURA
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332 ALIPHATIC LINEAR ,-UNSATURATED
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ALKOXY-SUBSTITUTED ALLYLBENZENES PR
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ALKOXY-SUBSTITUTED ALLYLBENZENES 35
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FURAN-SUBSTITUTED ALIPHATIC HYDROCA
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HYDROXY- AND ALKOXY-SUBSTITUTED BEN
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MISCELLANEOUS NITROGEN-CONTAINING S
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Page 582 and 583: MISCELLANEOUS NITROGEN-CONTAINING S
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Page 587 and 588: 580 SUBSTANCES STRUCTURALLY RELATED
Page 602: ANNEXES
Page 605 and 606: 598 ANNEX 1 10. Specifications for
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Page 615 and 616: 608 ANNEX 1 188. Safety evaluation
Page 617 and 618: 610 ANNEX 2 ECG electrocardiogram E
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Page 624 and 625: ANNEX 4 ACCEPTABLE DAILY INTAKES, O
Page 626 and 627: ANNEX 4 619 Food additive Specifica
Page 628 and 629: ANNEX 4 621 3. FLAVOURING AGENTS 3.
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Page 638 and 639: ANNEX 5 SUMMARY OF THE SAFETY EVALU
Page 640 and 641: ANNEX 5 633 Secondary components Co
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