Safety evaluation of certain food additives - ipcs inchem

414 ALKOXY-SUBSTITUTED ALLYLBENZENES
Table 4 (contd)
No. Flavouring agent End-point Test object Concentration Results References
81 μg/ml o (500 nmol/ml) Negative d Probst et al. (1981)
1792 Safrole Differential killing E. coli WP2 and
WP2uvrA Not provided Negative Suter & Jaeger (1982)
1792 Safrole Reverse mutation E. coli JC2921, JC2926,
JC5519 and JC5547
Ichinotsubo et al. (1981b)
500–1000 μg/ml Negativeg,y Positiveg,z 1792 Safrole Reverse mutation E. coli JC2921, JC5519,
JC7623, JC7689, JC8471
and JC9239
Weakly positived Venitt & Crofton-Sleigh
(1981)
1792 Safrole Differential killing E. coli WP2 and WP2uvrA 0.5, 1, 5, 10, 50 and 100 μg/
plate
Weakly positived Venitt & Crofton-Sleigh
(1981)
10, 20, 50, 100, 200 and 500
μg/plate
1792 Safrole Differential killing E. coli WP2 and WP2
uvrA
1792 Safrole Differential killing E. coli WP2/WP67 pol Up to 2000 μg/plate Negative Mamber et al. (1983)
1792 Safrole Differential killing E. coli polA + and polA 109 700 μg r (100 μl) Negative Fluck et al. (1976)
100 μg/ml Questionable d Green (1981)
1792 Safrole Differential killing E. coli WP2 and WP67
uvrA polA
Rosenkranz et al. (1981)
Not provided Negativeg Positivef 1792 Safrole Differential killing E. coli W3110(polA + ) and
P3478 (polA1 )
50, 100 and 200 μg/ml Positive g Tweats (1981)
1792 Safrole Differential killing E. coli WP2, WP67 (uvrA
polA) and CM871(uvrA
lexA recA)