Safety evaluation of certain food additives - ipcs inchem

FURAN-SUBSTITUTED ALIPHATIC HYDROCARBONS 531
and Extract Manufacturers Association, Washington, DC, USA. Submitted to WHO by the
International Organization of the Flavor Industry, Brussels, Belgium.
Reagan, E.L. & Becci, P.J. (1984b) Acute oral toxicity study in rats (isobutyl furyl
propionate). Unpublished report by Food and Drug Research Laboratories Inc. for the
Flavour and Extract Manufacturers Association, Washington, DC, USA. Submitted to WHO
by the International Organization of the Flavor Industry, Brussels, Belgium.
Reagan, E.L. & Becci, P.J. (1984c) Acute oral LD50 study of difurfuryl ether in Sprague-Dawley
rats. Unpublished report by Food and Drug Research Laboratories Inc. for the Flavour and
Extract Manufacturers Association, Washington, DC, USA. Submitted to WHO by the
International Organization of the Flavor Industry, Brussels, Belgium.
Rice, W.W. (1972) Furfural: Exogenous precursor of certain urinary furans and possible
toxicologic agent in humans. Clin. Chem., 18, 1550– 1551.
Richardson, K.A., Edward, V.T., Jones, B.C. & Hutson, D.H. (1991) Metabolism in the rat of
a model xenobiotic plant metabolite S-benzyl-N-malonyl-L-cysteine. Xenobiotica, 21, 371.
Ruangyuttikarn, W., Skiles, G.L. & Yost, G.S. (1992) Identification of a cysteinyl adduct
oxidized 3-methylindole from goat lung and human liver microsomal proteins. Chem. Res.
Toxicol., 5, 713–719.
Saraste, A. & Pulkki, K. (2000) Morphologic and biochemical hallmarks of apoptosis.
Cardiovasc. Res., 45, 528–537.
Scott, D., Galloway, S.M., Marshall, R.R., Ishidate, M., Brusick, D., Ashby, J. & Myhr, B.C.
(1991) Genotoxicity under extreme culture conditions. Mutat. Res., 257, 147–204.
Seeberg, A.H., Mosesso, P. & Forster, R. (1988) High-dose-level effects in mutagenicity
assays utilizing mammalian cells in culture. Mutagenesis, 3(3), 213–218.
Shellenberger, T.E. (1971a) Acute toxicological evaluations of chemicals with mice—2-amyl
furan (2-pentyl furan). Unpublished report to the Flavour and Extract Manufacturers
Association, Washington, DC, USA. Submitted to WHO by the International Organization
of the Flavor Industry, Brussels, Belgium.
Shellenberger, T.E. (1971b) Subacute (90-days) toxicity evaluation of 2-pentyl furan with
rats. Unpublished report to the Flavour and Extract Manufacturers Association,
Washington, DC, USA. Submitted to WHO by the International Organization of the Flavor
Industry, Brussels, Belgium.
Shellenberger, T.E. (1971c) Average adrenal weights of rats in 13-week subacute toxicity
feeding study of 2-pentyl-furan. Unpublished report to the Flavour and Extract
Manufacturers Association, Washington, DC, USA. Submitted to WHO by the International
Organization of the Flavor Industry, Brussels, Belgium.
Shinohara, K., Kin, E.-H. & Omura, H. (1986) Furans as mutagens formed by amino-carbonyl
reactions. In: M. Fujimaki, M. Namiki and H. Kato, eds. Amino-carbonyl reactions in food
and biological systems. Proceedings of the 3rd International Symposium on the Maillard
Reaction, Susono, Shizuoko, Japan, 1–5 July 1985. New York, NY, USA, Elsevier, pp.
353–362 (Developments in Food Science 13).
Sies, H., Brigelius, R. & Graf, P. (1987) Hormones, glutathione status and protein S-thiolation.
Adv. Enzyme Regul., 26, 175–184.
Stich, H.F., Rosin, M.P., Wu, C.H. & Powrie, W.D. (1981) Clastogenicity of furans found in
food. Cancer Lett., 13, 89–95.
Subramanyam, S., Sailaja, D. & Rathnaprabha, D. (1989) Genotoxic assay of two dietary
furans by some in vivo cytogenic parameters. Environ. Mol. Mutagen., 14(Suppl. 15), 239.
Sujatha, P.S. (2007) Genotoxic evaluation of furfuryl alcohol and 2-furyl methyl ketone by sister
chromatid exchange (SCE) analysis. J. Health Sci., 53(1), 124–127.
Sujatha, P.S., Jayanthi, A. & Subramanyam, S. (1993) Evaluation of the clastogenic potential
of 2-furyl methyl ketone in an in vivo mouse system. Med. Sci. Res., 21, 675–678.