Safety evaluation of certain food additives - ipcs inchem

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ANNEX 2 611 MAP mitogen-activated protein MPE micronucleated polychromatic erythrocyte MPSS-SE mixtures of phytosterols and phytostanols derived from solvent extraction MPSS-VD mixtures of phytosterols and phytostanols derived from vacuum distillation mRNA messenger ribonucleic acid MS mass spectrometry MSDI maximized survey-derived intake MS/MS tandem mass spectrometry MTD maximum tolerable dose; minimal toxic dose NADH reduced nicotinamide adenine dinucleotide NADP nicotinamide adenine dinucleotide phosphate NADPH reduced nicotinamide adenine dinucleotide phosphate NAS National Academy of Sciences NATCOL Natural Food Colours Association NCBI National Center for Biotechnology Information NDNS National Diet and Nutrition Survey nes not elsewhere specified NHANES National Health and Nutrition Examination Survey (USA) NMR nuclear magnetic resonance NNK 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone NNS National Nutrition Survey NOAEL no-observed-adverse-effect level NOEL no-observed-effect level NPC1L1 Niemann-Pick C1-Like 1 NRC National Research Council (USA) NTP National Toxicology Program (USA) ODC ornithine decarboxylase OECD Organisation for Economic Co-operation and Development PDB Protein Data Bank PDMS polydimethylsiloxane PE phytosterol ester PIR Protein Information Resource PND postnatal day POC phytosterol oxide concentrate ppm part per million PROCAM Prospective Cardiovascular Münster S9 9000 × g supernatant from rat liver SCE sister chromatid exchange SCF Scientific Committee on Food SD standard deviation SDAP Structural Database of Allergenic Proteins SDH sorbitol dehydrogenase; succinate dehydrogenase
612 ANNEX 2 SI stimulation index SULT sulfotransferase t½ half-life Tmax time taken to reach maximum plasma concentration TDS total diet study TNF tumour necrosis factor TOS total organic solids TTC threshold of toxicological concern UDS unscheduled DNA synthesis UKAS United Kingdom Accreditation Service UL tolerable upper level of intake USA United States of America USFDA United States Food and Drug Administration Vmax maximum rate v/v by volume VLDL very low density lipoprotein VODPSE vegetable oil–derived mixtures of phytostanol esters w/v weight by volume w/w by weight WDPSE wood-derived mixtures of phytostanol esters WHO World Health Organization
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WHO FOOD ADDITIVES SERIES: 60 Safet
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CONTENTS Preface ..................
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PREFACE The monographs contained in
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ASPARAGINASE FROM ASPERGILLUS NIGER
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16 CALCIUM LIGNOSULFONATE (40-65) 1
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18 CALCIUM LIGNOSULFONATE (40-65) ~
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20 CALCIUM LIGNOSULFONATE (40-65) A
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22 CALCIUM LIGNOSULFONATE (40-65) c
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24 CALCIUM LIGNOSULFONATE (40-65) T
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28 CALCIUM LIGNOSULFONATE (40-65) i
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ETHYL LAUROYL ARGINATE First draft
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ETHYL LAUROYL ARGINATE 41 and Devel
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ETHYL LAUROYL ARGINATE 43 lauroyl a
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ETHYL LAUROYL ARGINATE 45 arginine.
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ETHYL LAUROYL ARGINATE 47 resulting
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ETHYL LAUROYL ARGINATE 49 Table 4.
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ETHYL LAUROYL ARGINATE 51 weight ch
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ETHYL LAUROYL ARGINATE 53 stomach l
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ETHYL LAUROYL ARGINATE 55 fibrosis
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ETHYL LAUROYL ARGINATE 57 Table 5 (
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ETHYL LAUROYL ARGINATE 59 first 4 d
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ETHYL LAUROYL ARGINATE 61 The gener
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ETHYL LAUROYL ARGINATE 63 treatment
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ETHYL LAUROYL ARGINATE 65 gestation
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ETHYL LAUROYL ARGINATE 67 Body weig
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ETHYL LAUROYL ARGINATE 69 Table 6.
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ETHYL LAUROYL ARGINATE 77 About 99%
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ETHYL LAUROYL ARGINATE 79 concentra
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ETHYL LAUROYL ARGINATE 81 theoretic
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ETHYL LAUROYL ARGINATE 83 Huntingdo
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PAPRIKA EXTRACT First draft prepare
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PAPRIKA EXTRACT 87 of capsanthin ra
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PAPRIKA EXTRACT 89 biochemical para
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PAPRIKA EXTRACT 91 Table 1. Sales o
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PAPRIKA EXTRACT 93 Table 2. Estimat
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PAPRIKA EXTRACT 95 The European Sci
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PAPRIKA EXTRACT 97 The potential di
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PAPRIKA EXTRACT 99 Hornero-Mendez,
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PAPRIKA EXTRACT 101 Appendix 1. Res
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PAPRIKA EXTRACT 103 Appendix 1. (co
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PAPRIKA EXTRACT 105 Appendix 1. (co
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108 PHOSPHOLIPASE C EXPRESSED IN PI
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PHYTOSTEROLS, PHYTOSTANOLS AND THEI
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166 POLYDIMETHYLSILOXANE (addendum)
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STEVIOL GLYCOSIDES (addendum) First
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STEVIOL GLYCOSIDES (addendum) 185 r
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STEVIOL GLYCOSIDES (addendum) 187 c
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STEVIOL GLYCOSIDES (addendum) 189 a
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STEVIOL GLYCOSIDES (addendum) 191 N
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STEVIOL GLYCOSIDES (addendum) 193 2
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STEVIOL GLYCOSIDES (addendum) 195 T
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STEVIOL GLYCOSIDES (addendum) 197 a
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STEVIOL GLYCOSIDES (addendum) 199 r
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STEVIOL GLYCOSIDES (addendum) 201 l
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STEVIOL GLYCOSIDES (addendum) 203 g
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STEVIOL GLYCOSIDES (addendum) 209 t
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STEVIOL GLYCOSIDES (addendum) 211 t
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STEVIOL GLYCOSIDES (addendum) 213 s
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STEVIOL GLYCOSIDES (addendum) 215 C
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STEVIOL GLYCOSIDES (addendum) 217 L
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STEVIOL GLYCOSIDES (addendum) 219 W
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222 SULFITES: ASSESSMENT OF DIETARY
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SAFETY EVALUATIONS OF GROUPS OF REL
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264 INTRODUCTION Figure 1. Procedur
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DIETARY EXPOSURE ASSESSMENT OF FLAV
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292 ALIPHATIC BRANCHED-CHAIN SATURA
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332 ALIPHATIC LINEAR ,-UNSATURATED
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ALKOXY-SUBSTITUTED ALLYLBENZENES PR
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FURAN-SUBSTITUTED ALIPHATIC HYDROCA
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HYDROXY- AND ALKOXY-SUBSTITUTED BEN
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MISCELLANEOUS NITROGEN-CONTAINING S
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Page 568 and 569: MISCELLANEOUS NITROGEN-CONTAINING S
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Page 587 and 588: 580 SUBSTANCES STRUCTURALLY RELATED
Page 602: ANNEXES
Page 605 and 606: 598 ANNEX 1 10. Specifications for
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Page 615 and 616: 608 ANNEX 1 188. Safety evaluation
Page 617: 610 ANNEX 2 ECG electrocardiogram E
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Page 624 and 625: ANNEX 4 ACCEPTABLE DAILY INTAKES, O
Page 626 and 627: ANNEX 4 619 Food additive Specifica
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Page 630 and 631: ANNEX 4 623 Flavouring agent No. Sp
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Page 638 and 639: ANNEX 5 SUMMARY OF THE SAFETY EVALU
Page 640 and 641: ANNEX 5 633 Secondary components Co
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