Safety evaluation of certain food additives - ipcs inchem

ALKOXY-SUBSTITUTED ALLYLBENZENES 421
Table 4 (contd)
No. Flavouring agent End-point Test object Concentration Results References
Negative d Zdzienicka & Simons (1985)
1792 Safrole Forward mutation CHO cells 549, 1097 and 2743 μg/mlr (0.5, 1.0 and 2.5 μl/ml)
1792 Safrole Forward mutation Chinese hamster V79 cells 50, 100, 200 and 300 μg/ml Weakly positive ll Jain (1989)
1792 Safrole Forward mutation Chinese hamster V79 cells Not provided Positive Kuroda (1984)
10, 50 and 90 μg/ml Negative g Obe et al. (1985)
1792 Safrole SCE Human peripheral
lymphocytes
60 μg/ml Negative f Obe et al. (1985)
1792 Safrole SCE Human peripheral
lymphocytes
1792 Safrole SCE CHO cells 1.6, 5, 16, 25 and 50 μg/ml Positive g Gulati et al. (1985)
1792 Safrole SCE CHO cells 10, 30 and 50 μg/ml Positive g Gulati et al. (1985)
Positive f Gulati et al. (1985)
1792 Safrole SCE CHO cells 0.5, 1.6, 5, 16, 25 and
50 μg/ml
1792 Safrole SCE CHO cells 10, 30, 50 and 75 μg/ml Positive f Gulati et al. (1985)
1792 Safrole SCE CHO cells 12.5, 25, 50 and 100 μg/ml Negative d Lane et al. (1985)
Negative d Douglas et al. (1985)
1792 Safrole SCE CHO cells 8.1, 16.2, 48.6, 81, 97.2, 130,
162 and 324 μg/ml
van Went (1985)
Negativeg Positivef 1792 Safrole SCE Chinese hamster V79 cells 16.2, 81, 162 and 810 μg/mlo (104 , 5 × 104 , 103 and 5
×103 mol/l)