Safety evaluation of certain food additives - ipcs inchem

584 SUBSTANCES STRUCTURALLY RELATED TO MENTHOL (addendum)
Table 1 (contd)
Conclusion based on
current intake
Comments on
predicted metabolism
Flavouring agent No. CAS No. and structure Step A3d Does intake exceed the
threshold for human intake?
See note 3 No safety concern
No
Europe: ND
USA: ND
Japan: 0.03
d-2,8-p-Menthadien-1-ol 1861 22771-44-4
OH
CAS, Chemical Abstracts Service; ND, no intake data reported.
a Fourteen flavouring agents in this group were previously evaluated by the Committee (Annex 1, reference 137).
b Step 1: Five of the flavouring agents (Nos 1852–1855 and 1860) were assigned to structural class I, and the remaining five flavouring agents
(Nos 1856–1859 and 1861) were assigned to structural class II.
c Step 2: All of the agents in this group are expected to be metabolized to innocuous products.
d The thresholds for human intake for structural classes I and II are 1800 and 540 μg/day, respectively. All intake values are expressed in μg/day. The
combined per capita intakes of the five flavouring agents with the highest volume with the common metabolite, menthol, in structural class I are
1527 μg/day in Europe and 3513 μg/day in the USA.
Notes:
1. Anticipated to hydrolyse to their corresponding menthol derivative and carboxylic acid.
2. Menthol is primarily conjugated with glucuronic acid and excreted in the urine.
3. Anticipated to primarily conjugate with glucuronic acid and be excreted in the urine.
4. Anticipated to be reduced to the corresponding alcohol, primarily conjugate with glucuronic acid and be excreted in the urine.