Safety evaluation of certain food additives - ipcs inchem

300 ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS
Table 1 (contd)
Conclusion based on
current estimated intake
Comments on
predicted metabolism
Flavouring agent No. CAS No. and structure Step A3d Does the estimated
intake exceed the
threshold for human
intake?
See note 1 No safety concern
Structural class II
Methyl 2-methyl-2-propenoate 1834 80-62-6
No
Europe: 0.03
USA: ND
Japan: 0.03
O
O
CAS, Chemical Abstracts Service; ND, no intake data reported.
a Thirty-two flavouring agents belonging to the same chemical group were previously evaluated by the Committee at its sixty-first meeting (Annex 1,
reference 166).
b Step 1: Nineteen of the flavouring agents (Nos 1815–1833) in this group were assigned to structural class I, and the remaining flavouring agent (No.
1834) was assigned to structural class II.
c Step 2: All of the agents in this group are expected to be metabolized to innocuous products.
d The thresholds for human intake for structural classes I and II are 1800 and 540 μg/day, respectively. All intake values are expressed in μg/day.
Notes:
1. Hydrolysed to the corresponding alcohol and carboxylic acid, then participates in the pathway cited in notes 2 and 3.
2. Metabolized primarily via the -oxidation pathway, yielding shorter-chain carboxylic acids that are subsequently metabolized to carbon dioxide via
the tricarboxylic acid pathway.
3. Primarily oxidized to the corresponding carboxylic acid, which may enter the -oxidation pathway, yielding shorter-chain carboxylic acids that are
subsequently metabolized to carbon dioxide via the tricarboxylic acid pathway.
4. Oxidized to corresponding carboxylic acid. The acid may be excreted or undergo -oxidation to yield polar polyoxygenated metabolites that are
excreted free or conjugated primarily in the urine. If unsaturation is present, the polar polyoxygenated metabolites may also form hydrogenation or
hydration metabolites.
5. Hydrolysed to the corresponding alcohol and carboxylic acid, then participates in the pathway cited in notes 2 and 4.