Safety evaluation of certain food additives - ipcs inchem

418 ALKOXY-SUBSTITUTED ALLYLBENZENES
Table 4 (contd)
No. Flavouring agent End-point Test object Concentration Results References
S. cerevisiae D5 0–2500 μg/ml Positive Ferguson (1985)
1792 Safrole Induction of respiratory
mutation
Mehta & von Borstel
(1981)
1792 Safrole Haploid reversion S. cerevisiae XV185-14C 22.2–222 μg/ml Negativeg Positivef Negativeg Mehta & von Borstel
(1985)
10.96, 21.92, 43.84 and
87.68 μg/ml
1792 Safrole Haploid reversion S. cerevisiae D7-144, XV185-14C
and RM52
Positivef Mehta & von Borstel
(1985)
10.96, 21.92, 43.84 and
87.68 μg/ml
1792 Safrole Haploid reversion S. cerevisiae D7-144, XV185-14C
and RM52
Negative g Loprieno et al. (1985)
7, 66, 125, 209 and 626
μg/ml
1792 Safrole Forward mutation Schizosaccharomyces
pombe P1
Negative f Loprieno et al. (1985)
1792 Safrole Forward mutation S. pombe P1 20, 66, 125, 209 and 626
μg/ml
Negative g Loprieno (1981)
1792 Safrole Forward mutation S. pombe P1 0.003, 0.01 and
0.03 μg/ml
Positive f,gg Loprieno (1981)
1792 Safrole Forward mutation S. pombe P1 0.003, 0.01, 0.03 and 0.1
μg/ml
Negative Carere et al. (1985)
1792 Safrole Forward mutation Aspergillus nidulans 1096, 2740 and
5480 μg/ml
1792 Safrole Forward mutation L5178Y mouse lymphoma cells 10 and 25 μg/ml Negative To et al. (1982a)
1792 Safrole Forward mutation L5178Y mouse lymphoma cells Not provided Negative Lee & Webber (1985)
1792 Safrole Forward mutation L5178Y mouse lymphoma cells 88 μg/ml r (80 nl/ml) Negative g Myhr et al. (1985)