Safety evaluation of certain food additives - ipcs inchem

422 ALKOXY-SUBSTITUTED ALLYLBENZENES
Table 4 (contd)
No. Flavouring agent End-point Test object Concentration Results References
Negative g Evans & Mitchell (1981)
1792 Safrole SCE CHO cells 0.625–10 μg/ml
(0.000 625–0.01%)
1792 Safrole SCE CHO cells 1–8 μg/ml (0.001–0.008%) Negative f Evans & Mitchell (1981)
Negatived Natarajan & van
Kesteren-van Leeuwen
(1981)
1792 Safrole SCE CHO cells 0.1, 0.183 and 0.365 μg/mlr (0.10, 0.167 and 0.333 μl/ml)
Negative d Perry & Thomson (1981)
1792 Safrole SCE CHO cells 0.01, 0.1, 1, 10 and
100 μg/ml
50, 100, 200 and 300 μg/ml Weakly positive ll Jain (1989)
1792 Safrole SCE Chinese hamster V79
cells
16–49 μg/mlo (0.1–0.3 mmol/l) Positivemm Natarajan & Darroudi
(1991)
1792 Safrole SCE Human hepatoma
strain HepG2
Negative d Douglas et al. (1985)
1792 Safrole Micronucleus induction CHO cells 0.162–162 μg/mlo (106 –103 mol/l)
Negative d Kevekordes et al. (2001)
1792 Safrole Micronucleus induction CHO cells 0.162, 1.62, 16.2, 81, 162
and 243 μg/mlo (1, 10, 100, 500,
1000 and 1500 μmol/l)
16–195 μg/mlo (0.1–1.2 mmol/l) Positive Natarajan & Darroudi
(1991)
1792 Safrole Micronucleus induction Human hepatoma
strain HepG2
Positive d Ishidate & Sofuni (1985)
75, 100, 125, 150, 175 and
200 μg/ml
1792 Safrole Chromosomal aberration Chinese hamster lung
fibroblast cells