Safety evaluation of certain food additives - ipcs inchem

502 FURAN-SUBSTITUTED ALIPHATIC HYDROCARBONS
Table 2 (contd)
No. Flavouring agent Species; sex LD50
(mg/kg bw)
References
1498 2-Methyl-3(2-furyl)acrolein Rats; M, F 1400 Burdock & Ford
(1990d)
1502 2-Phenyl-3-(2-furyl)prop-2-enal Rats; M, F 717 Long (1977b)
1503 2-Furyl methyl ketone Rats; M, F 138 Piccirillo et al.
(1982)
1504 2-Acetyl-5-methylfuran Mice; M, F 438 Griffiths & Babish
(1978)
1504 2-Acetyl-5-methylfuran Mice; M, F 438 Moran et al.
(1980)
1514 Isobutyl 3-(2-furan)propionate Rats; M, F 3294 Piccirillo et al.
(1983b)
1514 Isobutyl 3-(2-furan)propionate Rats; M, F 4458 Reagan & Becci
(1984b)
1514 Isobutyl 3-(2-furan)propionate Rats; M, F 3300 Burdock & Ford
(1990c)
1514 Isobutyl 3-(2-furan)propionate Rats; NR 1950 Moreno (1977)
1522 Difurfuryl ether Rats; M, F 250 Burdock & Ford
(1990b)
1522 Difurfuryl ether Rats; M, F 249 Reagan & Becci
(1984c)
F, female; M, male; NR, not reported.
Male Sprague-Dawley rats weighing 150–200 g were given single
intraperitoneal injections of 2-methylfuran (No. 1487) at doses ranging from 50 to
400 mg/kg bw and were killed after 24 h. At 50 mg/kg bw, some hepatic endothelial
injury was produced. At 100 mg/kg bw, centrilobular hepatocytes showed early
necrosis. Extensive centrilobular necrosis was produced at 400 mg/kg bw. In
addition, injury to bronchiolar and bronchial epithelium was produced at 100 mg/kg
bw and progressed to necrosis at 400 mg/kg bw (Ravindranath et al., 1986).
2.2.2 Short-term studies of toxicity
The results of short-term studies with 10 representative furan-substituted
aliphatic hydrocarbons, alcohols, aldehydes, ketones, carboxylic acids and related
esters, sulfides, disulfides and ethers are summarized in Table 3 and described
below. One study was carried out with an alkyl-substituted furan derivative
(No. 1491), four studies with three furan-substituted ketones (Nos 1495, 1503, 1506
and 1511), two studies with two furan-substituted aldehydes (Nos 1497 and