Safety evaluation of certain food additives - ipcs inchem

430 ALKOXY-SUBSTITUTED ALLYLBENZENES
Table 4 (contd)
mm The authors noted that only the lowest concentration of 0.1 mmol/l showed a positive result. At higher concentrations, there were not enough
metaphases to evaluate SCE with the mitotic index reduced by 80%.
nn In the presence of metabolic activation with fixation after 3 h, aberrations were observed at 83.33 and 250 μg safrole/ml. In the presence of metabolic
activation with the fixation after 18 h, only the 83.33 μg/ml concentration showed significant chromosomal aberrations.
oo Dose-dependent increase in UDS observed.
pp In primary hepatocyte cultures as well as in liquid suspensions.
qq Administered via corn oil gavage.
rr Administered as ethanol solution in feeding assay.
ss Administered as a buffered dimethyl sulfoxide solution in feeding assay.
tt Administered in a feeding assay.
uu Safrole administered intraperitoneally.
vv Positive only in strains TA1950 and TA1952.
ww Only for strain TA1538 at 5500 mg/kg bw.
xx At 869 mg/kg bw for both strains and at 5500 mg/kg bw for strain TA1530.
yy One dose in one trial showed a positive result, but this was neither dose dependent nor repeatable.
zz Administered via intraperitoneal injection of corn oil suspension.
aaa Administered via single gavage dose.
bbb Administered in two doses via intraperitoneal injection.
ccc Tested positive in one phase but was not repeatable within the scope of this experiment.