Safety evaluation of certain food additives - ipcs inchem

MISCELLANEOUS NITROGEN-CONTAINING SUBSTANCES (addendum) 555
Table 1 (contd)
Conclusion based
on current
estimated intake
Comments
on predicted
metabolism
Step B4
Adequate margin of safety for
the flavouring agent or related substance?
No. CAS No. and structure Step B3d Does intake exceed
the threshold for
human intake?
Flavouring
agent
See note 1 No safety concern
Yes. The NOELe of 12 mg/kg bw per day
for the related substance allyl
isothiocyanate (No. 1560) (National
Toxicology Program, 1982) is 24 million
times the estimated daily intake of amyl
isothiocyanate when used as a flavouring
agent.
No
Europe: ND
USA: ND
Japan: 0.03
Structural class III
Amyl 1891 629-12-9
isothiocyanate
N C S
See note 1 No safety concern
Yes. The NOELe of 12 mg/kg bw per day
for the related substance allyl
isothiocyanate (No. 1560) (National
Toxicology Program, 1982) is 1.2 million
times the estimated daily intake of hexyl
isothiocyanate when used as a flavouring
agent.
No
Europe: ND
USA: ND
Japan: 0.8
1895 4404-45-9
Hexyl
isothiocyanate
N C S
CAS, Chemical Abstracts Service; ND, no intake data reported.
a Sixteen flavouring agents in this group were previously evaluated by the Committee at its sixty-fifth meeting (Annex 1, reference 177).
b Step 1: Twelve of the flavouring agents (Nos 1884–1890, 1892–1894, 1896 and 1897) in this group were assigned to structural class II, and the remaining
two flavouring agents (Nos 1891 and 1895) were assigned to structural class III.
c Step 2: None of the flavouring agents in this group can be predicted to be metabolized to innocuous products. In addition, there were toxicological concerns
associated with these substances.