Safety evaluation of certain food additives - ipcs inchem

ALKOXY-SUBSTITUTED ALLYLBENZENES 411
Table 4 (contd)
No. Flavouring agent End-point Test object Concentration Results References
250 μg/plate Negative d Simmon (1979a)
1792 Safrole Reverse mutation S. typhimurium TA98, TA100,
TA1535, TA1536, TA1537 and
TA1538
81 μg/ml o,s (500 nmol/ml) Negative d Probst et al. (1981)
1792 Safrole Reverse mutation S. typhimurium C3076, D3052,
G46, TA98, TA100, TA1535,
TA1537 and TA1538
Up to 1000 μg/plate Negative d McCann et al. (1975)
1792 Safrole Reverse mutation S. typhimurium TA98, TA100,
TA1535, TA1537 and TA1538
Up to 3600 μg/plate Negative d Gocke et al. (1981)
1792 Safrole Reverse mutation S. typhimurium TA98, TA100,
TA1535 and TA1538
Not provided Negative d Suter & Jaeger (1982)
1792 Safrole Reverse mutation S. typhimurium TA98, TA100,
TA1535 and TA1538
2.5–2000 μg/plate Negative d Rozenkranz & Poirier (1979)
1792 Safrole Reverse mutation S. typhimurium TA1535 and
TA1538
Negative d Zeiger & Haworth (1985)
1, 3.3, 10, 33, 67, 100 and 200
μg/plate
1792 Safrole Reverse mutation S. typhimurium TA97, TA98,
TA100 and TA1535
100 μg/ml Negative Nakamura et al. (1987)
1792 Safrole Reverse mutation S. typhimurium TA1535
(pSK1002)
1792 Safrole Reverse mutation S. typhimurium TA100 10, 30 and 100 μg/plate Negative f Cheh et al. (1980)
1792 Safrole Reverse mutation S. typhimurium TA100 50, 150 and 450 μg/plate Negative f Cheh et al. (1980)
Negative t Rexroat & Probst (1985)
50, 100, 500, 1000 and 5000 μg/
plate
1792 Safrole Reverse mutation S. typhimurium TA98, TA100,
TA1535, TA1537 and TA1538