Safety evaluation of certain food additives - ipcs inchem

ALKOXY-SUBSTITUTED ALLYLBENZENES 425
Table 4 (contd)
No. Flavouring agent End-point Test object Concentration Results References
Negative f Robinson & Mitchell (1981)
110–549 μg/mlr (0.1–0.5
μl/ml)
1792 Safrole UDS Human fibroblast WI-38
cells
1792 Safrole UDS HeLa S3 cells 0.1–100 μg/ml Negative d Martin & McDermid (1981)
Positive pp Michalopoulos et al. (1978)
1792 Safrole UDS Rat hepatocytes 0.000 162–1.62 μg/mlo (108 –105 mol/l)
Negative Klaunig et al. (1984)
1792 Safrole UDS Mouse hepatocytes 1.62–16.2 μg/mlo (105 –
104 mol/l)
1792 Safrole UDS Rat hepatocytes Not provided Positive Williams (1984)
In vivo
Positive Müller et al. (1994)
1789 Estragole UDS Rat (gavage) 500, 1000 and 2000 mg/kg
bw
Negative National Toxicology
Program (2008)
1789 Estragole Micronucleus induction Mouse (gavage) 37.5, 75, 150, 300 and 600
mg/kg bwqq Negative National Toxicology
Program (2000)
1790 Methyl eugenol Micronucleus induction Rat (gavage) 10, 30, 100, 300 and 1000
mg/kg bw
Negative Witt et al. (2000)
1790 Methyl eugenol Micronucleus induction Rat (gavage) 10, 30, 100, 300 and 1000
mg/kg bw
1790 Methyl eugenol UDS Rat (gavage) 500 mg/kg bw Positive Marshall & Caldwell (1996)
Drosophila melanogaster 2.5 mmol/l rr Negative Gocke et al. (1981)
1792 Safrole Sex-linked recessive lethal
mutation