Safety evaluation of certain food additives - ipcs inchem

ALKOXY-SUBSTITUTED ALLYLBENZENES 417
Table 4 (contd)
No. Flavouring agent End-point Test object Concentration Results References
1792 Safrole Mitotic recombination S. cerevisiae JD1 0–100 μg/ml Negative dd Sharp & Parry (1981a)
1792 Safrole Mitotic recombination S. cerevisiae JD1 0–100 μg/ml Positive ee Sharp & Parry (1981b)
1792 Safrole Mitotic recombination S. cerevisiae 100, 300, 600 and 750 μg/ml Negative g Sharp & Parry (1981b)
1792 Safrole Mitotic recombination S. cerevisiae 100, 300, 600 and 750 μg/ml Positive f,ff Sharp & Parry (1981b)
Negative d Jagannath et al. (1981)
1792 Safrole Mitotic recombination S. cerevisiae D4 0.33, 1.0, 3.33, 10.0, 33.33,
100.0 and 333.33 μg/plate
Positive d,j Schiestl et al. (1989a)
1792 Safrole Mitotic recombination S. cerevisiae RS9 110, 219 and 331 μg/mlo (0.68, 1.35 and 2.04 mmol/l)
Positive d,j Schiestl et al. (1989a)
1792 Safrole Mitotic recombination S. cerevisiae S42 55, 105 and 138 μg/mlo (0.34,
0.65 and 0.85 mmol/l)
1792 Safrole Genetic deletion S. cerevisiae RS112 2000–4000 μg/ml Positive Schiestl (1989)
S. cerevisiae RS112 Up to 2000 μg/ml Negative Schiestl (1989)
1792 Safrole Interchromosomal
recombination
1792 Safrole Interchromosomal S. cerevisiae RS112 0.5, 1, 2 and 4 μg/ml Positive
recombination
j Schiestl et al. (1989b)
1792 Safrole Mutation S. cerevisiae C658-K42 20, 40 and 80 μg/ml (0.02, Negative
0.04 and 0.08 mg/ml)
d Morita et al. (1989)
1792 Safrole Forward mutation S. cerevisiae PV-1 0.1–110 μg/ml Negative d Inge-Vechtomov et al. (1985)