Safety evaluation of certain food additives - ipcs inchem

ALKOXY-SUBSTITUTED ALLYLBENZENES 409
Table 4 (contd)
No. Flavouring agent End-point Test object Concentration Results References
Positive Burkey et al. (1999)
1790 Methyl eugenol UDS Mouse hepatocytes 1.78–178 μg/mli (10–1000
μmol/l)
Very weak positive Burkey et al. (1999)
1790 Methyl eugenol UDS Human hepatocytes 1.78–178 μg/mli (10–1000
μmol/l)
Positive k Burkey et al. (2000)
1790 Methyl eugenol UDS Mouse hepatocytes 0.0178–178 μg/mli (0.1–
1000 μmol/l)
Positive k Burkey et al. (2000)
1790 Methyl eugenol UDS Rat hepatocytes 0.0178–178 μg/mli (0.1–
1000 μmol/l)
1790 Methyl eugenol UDS Rat hepatocytes 1.25, 2.5, 5, 10 and 20 μg/ml Equivocal l San & Reece (2003)
Positive Sipes et al. (1999)
1790 Methyl eugenol UDS Rat hepatocytes 1.78–178 μg/mli (10–1000
μmol/l)
Negativen Hasheminejad & Caldwell
(1994)
1791 Myristicin UDS Rat hepatocytes 0.192–1922 μg/mlm (106 –
102 mol/l)
Negative d Swanson et al. (1979)
811–3244 μg/plateo (5–20
μmol/plate)
1792 Safrole Reverse mutation S. typhimurium TA98,
TA100 and TA1535
1792 Safrole Reverse mutation S. typhimurium TA100 1, 10 and 25 μg/ml Positive p To et al. (1982a)
Negative d To et al. (1982b)
0.05, 0.20, 1.0, 15 and 50
μg/plate
1792 Safrole Reverse mutation S. typhimurium TA98,
TA100, TA1535, TA1537
and TA1538
30, 90, 150 and 300 μg/plate Negatived Sekizawa & Shibamoto
(1982)
1792 Safrole Reverse mutation S. typhimurium TA98,
TA100, TA1535, TA1537
and TA1538