Safety evaluation of certain food additives - ipcs inchem

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MISCELLANEOUS NITROGEN-CONTAINING SUBSTANCES (addendum) 557 Table 2. Annual volumes <strong>of</strong> production <strong>of</strong> miscellaneous nitrogen-containing substances used as flavouring agents in Europe, the USA and Japan Flavouring agent (No.) Most recent annual volume (kg) a Intake b μg/day μg/kg bw per day Methyl isothiocyanate (1884) Europe ND ND ND USA ND ND ND Japan Ethyl isothiocyanate (1885) 0.1 0.03 0.0005 Europe ND ND ND USA ND ND ND Japan Isobutyl isothiocyanate (1886) 0.1 0.03 0.0005 Europe ND ND ND USA ND ND ND Japan Isoamyl isothiocyanate (1887) 10 3 0.05 Europe ND ND ND USA ND ND ND Japan Isopropyl isothiocyanate (1888) 0.1 0.03 0.0005 Europe ND ND ND USA ND ND ND Japan 3-Butenyl isothiocyanate (1889) 5 1 0.02 Europe ND ND ND USA ND ND ND Japan 2-Butylisothiocyanate (1890) 188 50 0.8 Europe ND ND ND USA ND ND ND Japan Amyl isothiocyanate (1891) 46 12 0.2 Europe ND ND ND
558 MISCELLANEOUS NITROGEN-CONTAINING SUBSTANCES (addendum) Table 2 (contd) Flavouring agent (No.) Most recent annual volume (kg) a Intake b μg/day μg/kg bw per day USA ND ND ND Japan 4-(Methylthio)butyl isothiocyanate (1892) 0.1 0.03 0.0005 Europe ND ND ND USA ND ND ND Japan 4-Pentenyl isothiocyanate (1893) 0.5 0.1 0.002 Europe ND ND ND USA ND ND ND Japan 5-Hexenyl isothiocyanate (1894) 500 132 2 Europe ND ND ND USA ND ND ND Japan Hexyl isothiocyanate (1895) 150 40 0.7 Europe ND ND ND USA ND ND ND Japan 5-(Methylthio)pentyl isothiocyanate (1896) 3 0.8 0.01 Europe ND ND ND USA ND ND ND Japan 6-(Methylthio)hexyl isothiocyanate (1897) 0.5 0.1 0.002 Europe ND ND ND USA ND ND ND Japan Total 10 3 0.05 Europe 0 USA 0 Japan 913
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WHO FOOD ADDITIVES SERIES: 60 Safet
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CONTENTS Preface ..................
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PREFACE The monographs contained in
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ASPARAGINASE FROM ASPERGILLUS NIGER
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16 CALCIUM LIGNOSULFONATE (40-65) 1
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18 CALCIUM LIGNOSULFONATE (40-65) ~
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20 CALCIUM LIGNOSULFONATE (40-65) A
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22 CALCIUM LIGNOSULFONATE (40-65) c
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24 CALCIUM LIGNOSULFONATE (40-65) T
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28 CALCIUM LIGNOSULFONATE (40-65) i
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ETHYL LAUROYL ARGINATE First draft
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ETHYL LAUROYL ARGINATE 41 and Devel
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ETHYL LAUROYL ARGINATE 43 lauroyl a
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ETHYL LAUROYL ARGINATE 45 arginine.
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ETHYL LAUROYL ARGINATE 47 resulting
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ETHYL LAUROYL ARGINATE 49 Table 4.
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ETHYL LAUROYL ARGINATE 51 weight ch
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ETHYL LAUROYL ARGINATE 53 stomach l
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ETHYL LAUROYL ARGINATE 55 fibrosis
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ETHYL LAUROYL ARGINATE 57 Table 5 (
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ETHYL LAUROYL ARGINATE 59 first 4 d
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ETHYL LAUROYL ARGINATE 61 The gener
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ETHYL LAUROYL ARGINATE 63 treatment
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ETHYL LAUROYL ARGINATE 65 gestation
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ETHYL LAUROYL ARGINATE 67 Body weig
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ETHYL LAUROYL ARGINATE 69 Table 6.
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ETHYL LAUROYL ARGINATE 77 About 99%
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ETHYL LAUROYL ARGINATE 79 concentra
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ETHYL LAUROYL ARGINATE 81 theoretic
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ETHYL LAUROYL ARGINATE 83 Huntingdo
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PAPRIKA EXTRACT First draft prepare
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PAPRIKA EXTRACT 87 of capsanthin ra
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PAPRIKA EXTRACT 89 biochemical para
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PAPRIKA EXTRACT 91 Table 1. Sales o
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PAPRIKA EXTRACT 93 Table 2. Estimat
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PAPRIKA EXTRACT 95 The European Sci
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PAPRIKA EXTRACT 97 The potential di
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PAPRIKA EXTRACT 99 Hornero-Mendez,
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PAPRIKA EXTRACT 101 Appendix 1. Res
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PAPRIKA EXTRACT 103 Appendix 1. (co
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PAPRIKA EXTRACT 105 Appendix 1. (co
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108 PHOSPHOLIPASE C EXPRESSED IN PI
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PHYTOSTEROLS, PHYTOSTANOLS AND THEI
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166 POLYDIMETHYLSILOXANE (addendum)
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STEVIOL GLYCOSIDES (addendum) First
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STEVIOL GLYCOSIDES (addendum) 185 r
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STEVIOL GLYCOSIDES (addendum) 187 c
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STEVIOL GLYCOSIDES (addendum) 189 a
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STEVIOL GLYCOSIDES (addendum) 191 N
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STEVIOL GLYCOSIDES (addendum) 193 2
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STEVIOL GLYCOSIDES (addendum) 195 T
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STEVIOL GLYCOSIDES (addendum) 197 a
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STEVIOL GLYCOSIDES (addendum) 199 r
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STEVIOL GLYCOSIDES (addendum) 201 l
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STEVIOL GLYCOSIDES (addendum) 203 g
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STEVIOL GLYCOSIDES (addendum) 209 t
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STEVIOL GLYCOSIDES (addendum) 211 t
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STEVIOL GLYCOSIDES (addendum) 213 s
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STEVIOL GLYCOSIDES (addendum) 215 C
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STEVIOL GLYCOSIDES (addendum) 217 L
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STEVIOL GLYCOSIDES (addendum) 219 W
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222 SULFITES: ASSESSMENT OF DIETARY
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SAFETY EVALUATIONS OF GROUPS OF REL
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264 INTRODUCTION Figure 1. Procedur
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DIETARY EXPOSURE ASSESSMENT OF FLAV
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292 ALIPHATIC BRANCHED-CHAIN SATURA
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332 ALIPHATIC LINEAR ,-UNSATURATED
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ALKOXY-SUBSTITUTED ALLYLBENZENES PR
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FURAN-SUBSTITUTED ALIPHATIC HYDROCA
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Page 514 and 515: FURAN-SUBSTITUTED ALIPHATIC HYDROCA
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Page 587 and 588: 580 SUBSTANCES STRUCTURALLY RELATED
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608 ANNEX 1 188. Safety evaluation
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610 ANNEX 2 ECG electrocardiogram E
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612 ANNEX 2 SI stimulation index SU
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614 ANNEX 3 Ms J. Baines, Food Stan
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ANNEX 4 ACCEPTABLE DAILY INTAKES, O
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ANNEX 4 619 Food additive Specifica
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ANNEX 4 621 3. FLAVOURING AGENTS 3.
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ANNEX 4 623 Flavouring agent No. Sp
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ANNEX 4 625 Flavouring agent JECFA
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ANNEX 4 627 Actual production volum
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ANNEX 4 629 Flavouring agent No. Sp
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ANNEX 5 SUMMARY OF THE SAFETY EVALU
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ANNEX 5 633 Secondary components Co
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