Safety evaluation of certain food additives - ipcs inchem

406 ALKOXY-SUBSTITUTED ALLYLBENZENES
Table 4. Studies of genotoxicity with methoxy- and methylenedioxy-substituted allylbenzenes administered orally
No. Flavouring agent End-point Test object Concentration Results References
In vitro
Positiveb Hasheminejad & Caldwell
(1994)
1788 Elemicin UDS Rat hepatocytes 0.208–2083 μg/mla (106 –
102 mol/l)
Weakly positive d,e Swanson et al. (1979)
741–2964 μg/platec (5–20
μmol/plate)
1789 Estragole Reverse mutation Salmonella typhimurium
TA98, TA100 and TA1535
To et al. (1982b)
Negativef Positiveg 0.05, 0.20, 1.0, 15 and 50
μg/plate
1789 Estragole Reverse mutation S. typhimurium TA98,
TA100, TA1535, TA1537
and TA1538
Negatived Sekizawa & Shibamoto
(1982)
30, 60, 120 and
300 μg/plate
1789 Estragole Reverse mutation S. typhimurium TA98,
TA100, TA1535, TA1537
and TA1538
30 μg/plate c (0.2 μmol/plate) Negative g Dorange et al. (1977)
1789 Estragole Reverse mutation S. typhimurium TA98,
TA100, TA1535, TA1537
and TA1538
1–200 μg/plate Negative d Zeiger et al. (1987)
1789 Estragole Reverse mutation S. typhimurium TA98,
TA100, TA1535, TA1537
and TA1538
1789 Estragole Reverse mutation Escherichia coli WP2 trp 30, 60, 120 and 300 μg/plate Negatived Sekizawa & Shibamoto
(1982)
4000 μg/disc Negativeg Sekizawa & Shibamoto
(1982)
1789 Estragole DNA repair Bacillus subtilis H17Rec +
and M45Rec