Safety evaluation of certain food additives - ipcs inchem

556 MISCELLANEOUS NITROGEN-CONTAINING SUBSTANCES (addendum)
Table 1 (contd)
d The thresholds of concern for structural classes II and III are 540 and 90 μg/day, respectively. All intake values are expressed in μg/day. The combined
per capita intakes of the five flavouring agents with the highest volume in a homologous series of linear saturated isothiocyanates in structural classes
II and III are 2 and 0.89 μg/person per day in Europe and Japan, respectively. The combined per capita intake of the four flavouring agents with the
highest volume in a homologous series of branched-chain saturated isothiocyanates in structural class II is 16 μg/person per day in Japan. The
combined per capita intakes of the four flavouring agents with the highest volume in a homologous series of linear saturated mercapto-isothiocyanates
in structural class II are 13, 52 and 3.2 μg/person per day in Europe, the USA and Japan, respectively. The combined per capita intakes of the four
flavouring agents with the highest volume in a homologous series of linear unsaturated isothiocyanates in structural class II are 1502, 133 and
222 μg/person per day in Europe, the USA and Japan, respectively.
e According to the decision taken by the Committee at its sixty-eighth meeting (Annex 1, reference 187), this would now be termed a NOAEL.
Note:
1. Rapidly absorbed, principally conjugated with glutathione and excreted in the urine.