Safety evaluation of certain food additives - ipcs inchem

ALKOXY-SUBSTITUTED ALLYLBENZENES 423
Table 4 (contd)
No. Flavouring agent End-point Test object Concentration Results References
1792 Safrole Chromosomal aberration CHO cells 27.77, 83.33 and 250 μg/ml Positive d,nn Palitti et al. (1985)
Negative g Gulati et al. (1985)
1792 Safrole Chromosomal aberration CHO cells 0.16, .5, 1.6, 5, 16, 50 and
160 μg/ml
1792 Safrole Chromosomal aberration CHO cells 40, 50, 75 and 100 μg/ml Negative g Gulati et al. (1985)
Negative f Gulati et al. (1985)
1792 Safrole Chromosomal aberration CHO cells 0.5, 1.6, 5, 16, 50 and
160 μg/ml
1792 Safrole Chromosomal aberration CHO cells 30, 40, 50 and 75 μg/ml Negative f Gulati et al. (1985)
Negatived Natarajan & van Kesterenvan
Leeuwen (1981)
1792 Safrole Chromosomal aberration CHO cells 110, 183 and 365 μg/mlr (0.10, 0.167 and 0.333 μl/ml)
6, 15, 30 and 60 μg/ml Negative Danford (1985)
1792 Safrole Chromosomal aberration Chinese hamster liver
fibroblast CH1-L cells
6, 15, 60 and 60 μg/ml Negative Parry (1985)
1792 Safrole Chromosomal aberration Chinese hamster liver
fibroblast CH1-L cells
1792 Safrole Chromosomal aberration Rat liver (RL 1 ) cells 25, 50 and 100 μg/ml Negative Dean (1981)
1792 Safrole Chromosomal aberration Chinese hamster V79 cells 50, 100, 200 and 300 μg/ml Negative ll Jain (1989)
Positive Bradley et al. (1987)
1792 Safrole Chromosomal aberration Rat hepatocytes 16.2, 49, 81, 122, 162 and
486 μg/mlo (0.1, 0.3, 0.5,
0.75, 1 and 3 mmol/l)
Positive Howes et al. (1990b)
1792 Safrole UDS Rat hepatocytes 0.162–162 μg/mlo (106 –
103 mol/l)