Safety evaluation of certain food additives - ipcs inchem

416 ALKOXY-SUBSTITUTED ALLYLBENZENES
Table 4 (contd)
No. Flavouring agent End-point Test object Concentration Results References
Positive g Kada (1981)
878–21940 μg/discr (0.0008–0.02 ml/disc)
1792 Safrole DNA repair B. subtilis H17Rec + and
M45Rec 1792 Safrole Mitotic recombination S. cerevisiae D3 1, 10 and 25 μg/ml Positive d To et al. (1982a)
1792 Safrole Mitotic recombination S. cerevisiae D3 19 μg/ml r (0.0175 μl/ml) Positive d Simmon (1979b)
1792 Safrole Mitotic recombination S. cerevisiae JD1 250, 500, 1000 and 2000 μg/ml Negative d Brooks et al. (1985)
0.1–110 μg/ml Negative d Inge-Vechtomov et al. (1985)
1792 Safrole Mitotic recombination S. cerevisiae PV-3 and
PV-3
Negative j Zimmermann et al. (1985)
1792 Safrole Mitotic recombination S. cerevisiae D61.M 27, 55, 68 and 81 μg/mlr (0.025, 0.050, 0.062 and
0.074 μl/ml)
1792 Safrole Mitotic recombination S. cerevisiae D7 3.3, 10, 30 and 90 μg/ml Negative d,j Arni (1985)
1792 Safrole Mitotic recombination S. cerevisiae D7 1.5, 3 and 6 μg/ml Negative d Arni (1985)
1792 Safrole Mitotic recombination S. cerevisiae D7 219 μg/ml r (200 nl/ml) Negative j Zimmermann & Scheel (1981)
Not provided Positive d Parry & Eckardt (1985)
1792 Safrole Mitotic recombination S. cerevisiae D61.M and
D6
1792 Safrole Mitotic recombination S. cerevisiae D6 0–100 μg/ml Negative f Parry & Sharp (1981)
1792 Safrole Mitotic recombination S. cerevisiae D6 0–100 μg/ml Positive g,bb Parry & Sharp (1981)
1792 Safrole Mitotic recombination S. cerevisiae T1 and T2 1–10 μg/ml Equivocal cc Kassinova et al. (1981)