Safety evaluation of certain food additives - ipcs inchem

552 MISCELLANEOUS NITROGEN-CONTAINING SUBSTANCES (addendum)
Table 1 (contd)
Conclusion based
on current
estimated intake
Comments
on predicted
metabolism
Step B4
Adequate margin of safety for
the flavouring agent or related substance?
No. CAS No. and structure Step B3d Does intake exceed
the threshold for
human intake?
Flavouring
agent
See note 1 No safety concern
Yes. The NOELe of 12 mg/kg bw per day for
the related substance allyl isothiocyanate
(No. 1560) (National Toxicology Program,
1982) is 24 million times the estimated daily
intake of isoamyl isothiocyanate when used
as a flavouring agent.
No
Europe: ND
USA: ND
Japan: 0.03
1887 628-03-5
Isoamyl
isothiocyanate
N C S
See note 1 No safety concern
Yes. The NOELe of 12 mg/kg bw per day for
the related substance allyl isothiocyanate
(No. 1560) (National Toxicology Program,
1982) is 600 000 times the estimated daily
intake of isopropyl isothiocyanate when
used as a flavouring agent.
No
Europe: ND
USA: ND
Japan: 1
1888 2253-73-8
Isopropyl
isothiocyanate
N C S
See note 1 No safety concern
Yes. The NOELe of 12 mg/kg bw per day for
the related substance allyl isothiocyanate
(No. 1560) (National Toxicology Program,
1982) is 15 000 times the estimated daily
intake of 3-butenyl isothiocyanate when
used as a flavouring agent.
No
Europe: ND
USA: ND
Japan: 50
1889 3386-97-8
3-Butenyl
isothiocyanate
N C S