Safety evaluation of certain food additives - ipcs inchem

HYDROXY- AND ALKOXY-SUBSTITUTED BENZYL DERIVATIVES (addendum) 537
Table 1 (contd)
Conclusion based
on current estimated
intake
Comments on
predicted metabolism
Flavouring agent No. CAS No. and structure Step A3d Does intake
exceed
the threshold for
human intake?
Structural class III
See note 1 No safety concern
No
Europe: 0.01
USA: 0.2
Japan: ND
Divanillin 1881 2092-49-1
O
H
OH
O
O
OH
O
H
CAS, Chemical Abstracts Service; ND, no intake data reported.
a Forty-six flavouring agents in this group were previously evaluated by the Committee (Annex 1, reference 154).
b Step 1: Five flavouring agents (Nos 1878–1880, 1882 and 1883) were assigned to structural class I, and the remaining flavouring agent (No. 1881)
was assigned to structural class III.
c Step 2: All the agents in this group are expected to be metabolized to innocuous products.
d The thresholds for human intake for structural classes I and III are 1800 and 90 μg/day, respectively. All intake values are expressed in μg/day. The
combined per capita intakes of the five flavouring agents with the highest volume with the common metabolite 4-hydroxy-3-methoxy benzoic acid were
60 826, 166 140 and 0.3 μg/person per day in Europe, the USA and Japan for all agents in the group, including the six agents evaluated at the present
meeting and those evaluated previously.