Safety evaluation of certain food additives - ipcs inchem

514 FURAN-SUBSTITUTED ALIPHATIC HYDROCARBONS
Table 4 (contd)
No. Flavouring agent End-point Test system Concentration/ dose Results References
Not specified Negative b Lee et al. (1994)
1488 2,5-Dimethylfuran Reverse mutation S. typhimurium TA98
and TA100
Up to 3333 μg/plate Negative b,c,d Zeiger et al. (1992)
1488 2,5-Dimethylfuran Reverse mutation S. typhimurium TA97,
TA98, TA100 and
TA1535
Negative/positiveb,h Shinohara et al.
(1986)
190, 1900 or
9500 μg/disc
1488 2,5-Dimethylfuran DNA damage B. subtilis H17 (rec+)
and M45 (rec)
1 mmol/l (96.13 μg/ml) g Negative Ochi & Ohsawa
(1985)
Chinese hamster V79
cells
1488 2,5-Dimethylfuran Chromosomal
aberration
Positive b,f Stich et al. (1981)
CHO cells 0-20 mmol/l
(0–1923 μg/ml) g
1488 2,5-Dimethylfuran Chromosomal
aberration
Negative b Asquith (1989)
3.2, 16, 80, 400 or
2000 μg/plate
Reverse mutation S. typhimurium TA98,
TA100, TA1535 and
TA1537
1494 3-Methyl-2-(3methylbut-2-enyl)-furan
1497 3-(2-Furyl)acrolein Reverse mutation S. typhimurium TA100 Not specified Negative b,c Eder et al. (1991)
Not specified Negative i Eder et al. (1991)
1497 3-(2-Furyl)acrolein DNA damage Escherichia coli PQ37
(SOS chromotest)
Not specified Weakly positive j Eder et al. (1993)
1497 3-(2-Furyl)acrolein DNA damage E. coli PQ37 (SOS
chromotest)
Negative/positiveb,k Shinohara et al.
(1986)
0.165, 0.330, 0.495 or
0.660 μmol/plate
(13.5, 27.1, 40.6 or
54.2 μg/plate) j
1503 2-Furyl methyl ketone Reverse mutation S. typhimurium TA98
and TA100