Safety evaluation of certain food additives - ipcs inchem

ALKOXY-SUBSTITUTED ALLYLBENZENES 385
Table 3. Results of short-term studies of toxicity and long-term studies of
toxicity and carcinogenicity with methoxy- and methylenedioxy-substituted
allylbenzenes present in foods and essential oils and used as flavouring
agents
No. Flavouring
agent
Species;
sex
Short-term studies of toxicity
1789 Estragole Mouse; M,
F
No. of
test
groups a /
no. per
group b
Route Duration
(days)
NOEL c /
NOAEL d
(mg/kg bw
per day)
Reference
5/20 Gavage 93 37.5 d National
Toxicology
Program
(2008)
1789 Estragole Rat; M, F 5/20 Gavage 93 37.5 d,e National
Toxicology
Program
(2008)
1790 Methyl
eugenol
1790 Methyl
eugenol
1790 Methyl
eugenol
1790 Methyl
eugenol
Mouse; M,
F
5/20 Gavage 90 10 d National
Toxicology
Program
(2000)
Rat; M, F 5/20 Gavage 90 30 d National
Toxicology
Program
(2000)
Mouse; M,
F
3/20 Diet 28 50 Jones (2004)
Rat; M, F 2/24 Diet 91 18 d,e Osborne
et al. (1981)
1791 Myristicin Rat; M, F 1/12 Diet 26 10 c,e Truitt et al.
(1961)
1791 Myristicin Rat; M, F 3/20 Gavage 28 8.3 d,f Mills (1989)
1792 Safrole Rat; M, F 3/20 Gavage 28 8.3 d,g Mills (1989)
1792 Safrole Rat; M, F 3/10 Gavage 105 250 d,e Hagan et al.
(1965)
Long-term studies of toxicity
1789 Estragole Mouse; F 2/30, 50 Diet 600 150–300d,e,h Miller et al.
(1983)
1789 Estragole Mouse; M,
F
1790 Methyl
eugenol
Mouse; M,
F
1/104 Gavage 420 370 d,e,i Miller et al.
(1983)
4/100 Gavage 730 37 d,e,j National
Toxicology
Program
(2000)