Safety evaluation of certain food additives - ipcs inchem

516 FURAN-SUBSTITUTED ALIPHATIC HYDROCARBONS
Table 4 (contd)
No. Flavouring agent End-point Test system Concentration/ dose Results References
130, 240 or 280 μg/ml Positive i,s Meerts (2000)
Human peripheral
lymphocytes
Chromosomal
aberration
1526 O-Ethyl-S-(2-furylmethyl)thiocarbonate
100, 130 or 240 μg/ml Positive i,t Meerts (2000)
Human peripheral
lymphocytes
Chromosomal
aberration
1526 O-Ethyl-S-(2-furylmethyl)thiocarbonate
Meerts (2000)
150, 325 or 375 μg/ml Negative/
positiver,u,v Human peripheral
lymphocytes
Chromosomal
aberration
1526 O-Ethyl-S-(2-furylmethyl)thiocarbonate
In vivo
Negative Subramanyam et al.
(1989)
1000, 2000 or 4000
mg/kg (100, 200 or
400 mg/kg bw per
day) w
Mouse bone marrow
cells and
spermatocytes
1487 2-Methylfuran Chromosomal
aberration
Positive y,z Sujatha et al. (1993)
Mouse bone marrow 1000, 2000 or 3000
mg/l (20, 40 or 60 mg/
kg bw) x
1503 2-Furyl methyl ketone Chromosomal
aberration
Negative aa Sujatha et al. (1993)
Mouse spermatocytes 1000, 2000 or 3000
mg/l (20, 40 or 60 mg/
kg bw) x
1503 2-Furyl methyl ketone Chromosomal
aberration
Positive Sujatha (2007)
1503 2-Furyl methyl ketone SCE Mouse bone marrow 1000, 2000 or 3000
mg/l (20, 40 or 60 mg/
kg bw) x
1503 2-Furyl methyl ketone UDS Rat liver 7 or 21 mg/kg bw Negative Durward (2007b)
Negative Verspeek-Rip (2001)
Mouse bone marrow 100, 250 or 500 mg/kg
bwbb Micronucleus
induction
1526 O-Ethyl-S-(2-furylmethyl)thiocarbonate