Safety evaluation of certain food additives - ipcs inchem

ALKOXY-SUBSTITUTED ALLYLBENZENES 413
Table 4 (contd)
No. Flavouring agent End-point Test object Concentration Results References
Weakly positived Venitt & Crofton-Sleigh
(1981)
0.5, 1, 5, 10, 50 and 100 μg/
plate
1792 Safrole Reverse mutation S. typhimurium TA98 and
TA100
Weakly positived Venitt & Crofton-Sleigh
(1981)
10, 20, 50, 100, 200 and 500
μg/plate
1792 Safrole Reverse mutation S. typhimurium TA98 and
TA100
Not provided Negative d Nagao & Takahashi (1981)
1792 Safrole Reverse mutation S. typhimurium TA98,
TA100 and TA1537
0.1, 1, 10 and 100 μg/plate Negative d Richold & Jones (1981)
1792 Safrole Reverse mutation S. typhimurium TA98,
TA100, TA1535, TA1537
and TA1538
Up to 1000 μg/plate Negative d Ichinotsubo et al. (1981a)
1792 Safrole Reverse mutation S. typhimurium TA98 and
TA100
1, 10, 100 and 500 μg/plate Negative d Hubbard et al. (1981)
1792 Safrole Reverse mutation S. typhimurium TA98 and
TA100
1792 Safrole Reverse mutation S. typhimurium TA102 Up to 5000 μg/plate Negative Müller et al. (1993)
1792 Safrole Reverse mutation S. typhimurium TM677 50, 200 and 500 μg/ml Negative d Liber (1985)
1792 Safrole Reverse mutation S. typhimurium TM677 Up to 1000 μg/ml Negative d Skopek et al. (1981)
1792 Safrole Reverse mutation S. typhimurium TA98 1–1000 μg/ml Negative d Gatehouse (1981)
1792 Safrole Reverse mutation S. typhimurium TA1535 1–1000 μg/ml Positive g Gatehouse (1981)
1792 Safrole Differential killing E. coli WP2 uvrA 1–1000 μg/ml Negative f Gatehouse (1981)
1792 Safrole Differential killing E. coli WP2 trp 30, 90, 150 and 300 μg/plate Negatived Sekizawa & Shibamoto
(1982)