Safety evaluation of certain food additives - ipcs inchem

420 ALKOXY-SUBSTITUTED ALLYLBENZENES
Table 4 (contd)
No. Flavouring agent End-point Test object Concentration Results References
Negative g Mitchell et al. (1988)
1792 Safrole Forward mutation L5178Y mouse lymphoma cells 39–151 μg/mlr (0.036–0.138
μl/ml)
1792 Safrole Forward mutation L5178Y mouse lymphoma cells 16–39 μg/ml r (0.015–0.036 μl/ml) Positive f Mitchell et al. (1988)
1792 Safrole Forward mutation L5178Y mouse lymphoma cells 5–36 μg/ml r (0.005–0.03 μl/ml) Positive f Mitchell et al. (1988)
1792 Safrole Forward mutation L5178Y mouse lymphoma cells 20, 30, 40, 50, 60 and 70 μg/ml Negative g Oberly et al. (1984)
Negative f Oberly et al. (1984)
1792 Safrole Forward mutation L5178Y mouse lymphoma cells 0.625, 1.25, 2.5, 5.0, 7.5 and 10
μg/ml
1792 Safrole Forward mutation Chinese hamster V79 cells Not provided Negative Lee & Webber (1985)
Negative d Kuroki & Munakata (1985)
1792 Safrole Forward mutation Chinese hamster V79 cells 1.62, 16.2 and 162 μg/mlo (0.01,
0.1 and 1 mol/l)
1792 Safrole Forward mutation Human lymphoblast cells TK6 100, 200, 500 and 1000 μg/ml Negative g Crespi et al. (1985)
1792 Safrole Forward mutation Human lymphoblast cells TK6 125, 250, 375, 500 and 625 μg/ml Positive f,kk Crespi et al. (1985)
40, 80, 120 and 160 μg/ml Negative Crespi et al. (1985)
1792 Safrole Forward mutation Human lymphoblast cells
AHH-1
1792 Safrole Forward mutation Chinese hamster V79 cells 100, 200 and 300 μg/ml Positive g Kuroda et al. (1985)
Negative d Fox & Delow (1985)
1792 Safrole Forward mutation Chinese hamster V79 cells 25, 50 and 100 μg/ml (0.025,
0.050 and 0.1 mg/ml)