Safety evaluation of certain food additives - ipcs inchem

46 ETHYL LAUROYL ARGINATE
Figure 1. Biotransformation pathway of ethyl lauroyl arginate
HO
H 2N
NH
H
N
Lauric acid
NH 2
O
L-Arginine ethyl ester
Minor pathway
Ethanol
O
NH 2
H 2N
NH
L-Ornithine
Carbon dioxide
H
N
O
L-Arginine
NH 2
+
NH 2
O
O
H
N
Ethyl lauroyl arginate
OH
H 2 N
Urea
NH 2
O
O O
carcass, including 3.4 ± 0.4% in the liver. The low rate of excretion in the faeces
indicated that ethyl lauroyl arginate–derived material was almost completely
absorbed. Analysis of the urine (0–24 h) showed that the major metabolite cochromatographed
with urea, although the identity of this metabolite was not
confirmed. This metabolite represented a mean of 7.7% of the dose in urine. Six
other radioactive components were detected in the urine, all of which represented
0.2% of the dose.
The authors concluded that ethyl lauroyl arginate was rapidly metabolized
to the amino acid arginine, which then underwent normal amino acid catabolism,
HO
Lauric acid
O
N
H
NH
N
H
Major pathway
NH 2
HN NH 2
NH
Ethanol
O
N α -Lauroyl-L-arginine