Safety evaluation of certain food additives - ipcs inchem

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HYDROXY- AND ALKOXY-SUBSTITUTED BENZYL DERIVATIVES (addendum) 547 Table 5 (contd) No. Flavouring agent End-point Test object Concentration Results References Negatived Van Delft & de Vogel (1998) Chinese hamster ovary 0, 232, 464, 696, 928, 1160, 1741 and 2321 μg/mlb (0, 1, 2, 3, 4, 5, 7.5 and 10 mmol/l) Chromosomal aberration 1880 Sodium 4-methoxybenzoyloxyacetate Negative a King (2002) 0, 50, 150, 500, 1500 and 5000e μg/plate S. typhimurium TA98, TA100, TA102, TA1535 and TA1537 1881 Divanillin Reverse mutation Negative a King (2002) 0, 15, 50, 150, 500 and 1500 μg/plate S. typhimurium TA98, TA100, TA102, TA1535 and TA1537 1881 Divanillin Reverse mutation a With and without metabolic activation. b Calculated using the relative molecular mass of sodium 4-methoxybenzoyloxyacetate = 232.1. c With metabolic activation. d Without metabolic activation. e Precipitation was observed in assays conducted at 1500 and 5000 μg/plate.
548 HYDROXY- AND ALKOXY-SUBSTITUTED BENZYL DERIVATIVES (addendum) King, M.-T. (2002) Mutagenicity study of HR 02/G05025 in the Salmonella typhimurium/ mammalian microcosm reverse mutation assay (Ames-Test). Project No. AM.602N. Unpublished report by Freiburger Labor für Mutagenitätsprüfung, Kirchzarten, Germany, for the Flavor and Extract Manufacturers Association, Washington, DC, USA. Submitted to WHO by the International Organization of the Flavour Industry, Brussels, Belgium. Lina, B.A.R. (1999) Sub-chronic (13-week) oral toxicity study with 4-MBA in rats. Project No. 481136. Unpublished report by TNO Nutrition and Food Research Institute, Zeist, Netherlands, for the Flavor and Extract Manufacturers Association, Washington, DC, USA. Submitted to WHO by the International Organization of the Flavour Industry, Brussels, Belgium. Meuling, W. & de Bie, A.T.H.J. (1999) Urinary excretion of 4-MBA and metabolites in human volunteers after oral administration of 4-MBA. Project No. 40792. Unpublished report by TNO Nutrition and Food Research Institute, Zeist, Netherlands, for the Flavor and Extract Manufacturers Association, Washington, DC, USA. Submitted to WHO by the International Organization of the Flavour Industry, Brussels, Belgium. Nijssen, B., van Ingen-Visscher, K. & Donders, J. (2007) VCF (Volatile Compounds in Foods) database. Zeist, Netherlands, TNO Nutrition and Food Research (http://www.vcf-online.nl/ VcfHome.cfm; Version 9.2 accessed September 2007). Reitz, G. (1995) Hydrolysis of vanillin TK-10 acetal (TAK#935011). Unpublished report to the Flavor and Extract Manufacturers Association, Washington, DC, USA. Submitted to WHO by the International Organization of the Flavour Industry, Brussels, Belgium. Van Delft, J.H.M. (1998a) Gene mutation test at the TK-locus of L5178Y cells with 4-MBA. Project No. 480041/001. Unpublished report by TNO Nutrition and Food Research Institute, Zeist, Netherlands, for the Flavor and Extract Manufacturers Association, Washington, DC, USA. Submitted to WHO by the International Organization of the Flavour Industry, Brussels, Belgium. Van Delft, J.H.M. (1998b) Bacterial gene mutation test with 4-MBA. Project No. 480064/002. Unpublished report by TNO Nutrition and Food Research Institute, Zeist, Netherlands, for the Flavor and Extract Manufacturers Association, Washington, DC, USA. Submitted to WHO by the International Organization of the Flavour Industry, Brussels, Belgium. Van Delft, J.H.M. & de Vogel, N. (1998) Chromosome aberration test with 4-MBA in cultured Chinese hamster ovary cells. Project No. 480040/001. Unpublished report by TNO Nutrition and Food Research Institute, Zeist, Netherlands, for the Flavor and Extract Manufacturers Association, Washington, DC, USA. Submitted to WHO by the International Organization of the Flavour Industry, Brussels, Belgium. Wolterbeek, A.P.M. & Waalkens-Berendsen, D.H. (1999) Oral embryotoxicity/teratogenicity study with 4-MBA in rats. Project No. 481144. Unpublished report by TNO Nutrition and Food Research Institute, Zeist, Netherlands, for the Flavor and Extract Manufacturers Association, Washington, DC, USA. Submitted to WHO by the International Organization of the Flavour Industry, Brussels, Belgium.
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WHO FOOD ADDITIVES SERIES: 60 Safet
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CONTENTS Preface ..................
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PREFACE The monographs contained in
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ASPARAGINASE FROM ASPERGILLUS NIGER
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16 CALCIUM LIGNOSULFONATE (40-65) 1
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18 CALCIUM LIGNOSULFONATE (40-65) ~
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20 CALCIUM LIGNOSULFONATE (40-65) A
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22 CALCIUM LIGNOSULFONATE (40-65) c
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24 CALCIUM LIGNOSULFONATE (40-65) T
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28 CALCIUM LIGNOSULFONATE (40-65) i
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ETHYL LAUROYL ARGINATE First draft
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ETHYL LAUROYL ARGINATE 41 and Devel
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ETHYL LAUROYL ARGINATE 43 lauroyl a
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ETHYL LAUROYL ARGINATE 45 arginine.
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ETHYL LAUROYL ARGINATE 47 resulting
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ETHYL LAUROYL ARGINATE 49 Table 4.
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ETHYL LAUROYL ARGINATE 51 weight ch
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ETHYL LAUROYL ARGINATE 53 stomach l
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ETHYL LAUROYL ARGINATE 55 fibrosis
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ETHYL LAUROYL ARGINATE 57 Table 5 (
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ETHYL LAUROYL ARGINATE 59 first 4 d
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ETHYL LAUROYL ARGINATE 61 The gener
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ETHYL LAUROYL ARGINATE 63 treatment
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ETHYL LAUROYL ARGINATE 65 gestation
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ETHYL LAUROYL ARGINATE 67 Body weig
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ETHYL LAUROYL ARGINATE 69 Table 6.
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ETHYL LAUROYL ARGINATE 77 About 99%
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ETHYL LAUROYL ARGINATE 79 concentra
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ETHYL LAUROYL ARGINATE 81 theoretic
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ETHYL LAUROYL ARGINATE 83 Huntingdo
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PAPRIKA EXTRACT First draft prepare
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PAPRIKA EXTRACT 87 of capsanthin ra
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PAPRIKA EXTRACT 89 biochemical para
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PAPRIKA EXTRACT 91 Table 1. Sales o
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PAPRIKA EXTRACT 93 Table 2. Estimat
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PAPRIKA EXTRACT 95 The European Sci
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PAPRIKA EXTRACT 97 The potential di
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PAPRIKA EXTRACT 99 Hornero-Mendez,
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PAPRIKA EXTRACT 101 Appendix 1. Res
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PAPRIKA EXTRACT 103 Appendix 1. (co
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PAPRIKA EXTRACT 105 Appendix 1. (co
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108 PHOSPHOLIPASE C EXPRESSED IN PI
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PHYTOSTEROLS, PHYTOSTANOLS AND THEI
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166 POLYDIMETHYLSILOXANE (addendum)
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STEVIOL GLYCOSIDES (addendum) First
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STEVIOL GLYCOSIDES (addendum) 185 r
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STEVIOL GLYCOSIDES (addendum) 187 c
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STEVIOL GLYCOSIDES (addendum) 189 a
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STEVIOL GLYCOSIDES (addendum) 191 N
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STEVIOL GLYCOSIDES (addendum) 193 2
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STEVIOL GLYCOSIDES (addendum) 195 T
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STEVIOL GLYCOSIDES (addendum) 197 a
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STEVIOL GLYCOSIDES (addendum) 199 r
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STEVIOL GLYCOSIDES (addendum) 201 l
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STEVIOL GLYCOSIDES (addendum) 203 g
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STEVIOL GLYCOSIDES (addendum) 209 t
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STEVIOL GLYCOSIDES (addendum) 211 t
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STEVIOL GLYCOSIDES (addendum) 213 s
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STEVIOL GLYCOSIDES (addendum) 215 C
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STEVIOL GLYCOSIDES (addendum) 217 L
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STEVIOL GLYCOSIDES (addendum) 219 W
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222 SULFITES: ASSESSMENT OF DIETARY
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SAFETY EVALUATIONS OF GROUPS OF REL
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264 INTRODUCTION Figure 1. Procedur
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DIETARY EXPOSURE ASSESSMENT OF FLAV
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292 ALIPHATIC BRANCHED-CHAIN SATURA
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332 ALIPHATIC LINEAR ,-UNSATURATED
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ALKOXY-SUBSTITUTED ALLYLBENZENES PR
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ALKOXY-SUBSTITUTED ALLYLBENZENES 35
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FURAN-SUBSTITUTED ALIPHATIC HYDROCA
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Page 504 and 505: FURAN-SUBSTITUTED ALIPHATIC HYDROCA
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Page 587 and 588: 580 SUBSTANCES STRUCTURALLY RELATED
Page 602: ANNEXES
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598 ANNEX 1 10. Specifications for
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600 ANNEX 1 No. 54, 1974; WHO Techn
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602 ANNEX 1 70. Evaluation of certa
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604 ANNEX 1 108. Toxicological eval
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606 ANNEX 1 148. Residues of some v
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608 ANNEX 1 188. Safety evaluation
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610 ANNEX 2 ECG electrocardiogram E
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612 ANNEX 2 SI stimulation index SU
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614 ANNEX 3 Ms J. Baines, Food Stan
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ANNEX 4 ACCEPTABLE DAILY INTAKES, O
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ANNEX 4 619 Food additive Specifica
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ANNEX 4 621 3. FLAVOURING AGENTS 3.
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ANNEX 4 623 Flavouring agent No. Sp
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ANNEX 4 625 Flavouring agent JECFA
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ANNEX 4 627 Actual production volum
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ANNEX 4 629 Flavouring agent No. Sp
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ANNEX 5 SUMMARY OF THE SAFETY EVALU
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ANNEX 5 633 Secondary components Co
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