Safety evaluation of certain food additives - ipcs inchem

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MISCELLANEOUS NITROGEN-CONTAINING SUBSTANCES (addendum) 551 Table 1. Summary of the results of safety evaluations of miscellaneous nitrogen-containing substances used as flavouring agentsa,b,c Conclusion based on current estimated intake Comments on predicted metabolism Step B4 Adequate margin of safety for the flavouring agent or related substance? No. CAS No. and structure Step B3d Does intake exceed the threshold for human intake? Flavouring agent See note 1 No safety concern Yes. The NOELe of 12 mg/kg bw per day for the related substance allyl isothiocyanate (No. 1560) (National Toxicology Program, 1982) is 24 million times the estimated daily intake of methyl isothiocyanate when used as a flavouring agent. No Europe: ND USA: ND Japan: 0.03 Structural class II Methyl 1884 556-61-6 isothiocyanate N C S See note 1 No safety concern Yes. The NOELe of 12 mg/kg bw per day for the related substance allyl isothiocyanate (No. 1560) (National Toxicology Program, 1982) is 24 million times the estimated daily intake of ethyl isothiocyanate when used as a flavouring agent. No Europe: ND USA: ND Japan: 0.03 1885 542-85-8 Ethyl isothiocyanate N C S See note 1 No safety concern Yes. The NOELe of 12 mg/kg bw per day for the related substance allyl isothiocyanate (No. 1560) (National Toxicology Program, 1982) is 240 000 times the estimated daily intake of isobutyl isothiocyanate when used as a flavouring agent. No Europe: ND USA: ND Japan: 3 1886 591-82-2 Isobutyl isothiocyanate N C S
552 MISCELLANEOUS NITROGEN-CONTAINING SUBSTANCES (addendum) Table 1 (contd) Conclusion based on current estimated intake Comments on predicted metabolism Step B4 Adequate margin of safety for the flavouring agent or related substance? No. CAS No. and structure Step B3d Does intake exceed the threshold for human intake? Flavouring agent See note 1 No safety concern Yes. The NOELe of 12 mg/kg bw per day for the related substance allyl isothiocyanate (No. 1560) (National Toxicology Program, 1982) is 24 million times the estimated daily intake of isoamyl isothiocyanate when used as a flavouring agent. No Europe: ND USA: ND Japan: 0.03 1887 628-03-5 Isoamyl isothiocyanate N C S See note 1 No safety concern Yes. The NOELe of 12 mg/kg bw per day for the related substance allyl isothiocyanate (No. 1560) (National Toxicology Program, 1982) is 600 000 times the estimated daily intake of isopropyl isothiocyanate when used as a flavouring agent. No Europe: ND USA: ND Japan: 1 1888 2253-73-8 Isopropyl isothiocyanate N C S See note 1 No safety concern Yes. The NOELe of 12 mg/kg bw per day for the related substance allyl isothiocyanate (No. 1560) (National Toxicology Program, 1982) is 15 000 times the estimated daily intake of 3-butenyl isothiocyanate when used as a flavouring agent. No Europe: ND USA: ND Japan: 50 1889 3386-97-8 3-Butenyl isothiocyanate N C S
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WHO FOOD ADDITIVES SERIES: 60 Safet
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CONTENTS Preface ..................
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PREFACE The monographs contained in
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ASPARAGINASE FROM ASPERGILLUS NIGER
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16 CALCIUM LIGNOSULFONATE (40-65) 1
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18 CALCIUM LIGNOSULFONATE (40-65) ~
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20 CALCIUM LIGNOSULFONATE (40-65) A
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22 CALCIUM LIGNOSULFONATE (40-65) c
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24 CALCIUM LIGNOSULFONATE (40-65) T
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28 CALCIUM LIGNOSULFONATE (40-65) i
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ETHYL LAUROYL ARGINATE First draft
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ETHYL LAUROYL ARGINATE 41 and Devel
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ETHYL LAUROYL ARGINATE 43 lauroyl a
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ETHYL LAUROYL ARGINATE 45 arginine.
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ETHYL LAUROYL ARGINATE 47 resulting
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ETHYL LAUROYL ARGINATE 49 Table 4.
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ETHYL LAUROYL ARGINATE 51 weight ch
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ETHYL LAUROYL ARGINATE 53 stomach l
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ETHYL LAUROYL ARGINATE 55 fibrosis
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ETHYL LAUROYL ARGINATE 57 Table 5 (
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ETHYL LAUROYL ARGINATE 59 first 4 d
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ETHYL LAUROYL ARGINATE 61 The gener
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ETHYL LAUROYL ARGINATE 63 treatment
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ETHYL LAUROYL ARGINATE 65 gestation
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ETHYL LAUROYL ARGINATE 67 Body weig
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ETHYL LAUROYL ARGINATE 69 Table 6.
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ETHYL LAUROYL ARGINATE 77 About 99%
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ETHYL LAUROYL ARGINATE 79 concentra
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ETHYL LAUROYL ARGINATE 81 theoretic
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ETHYL LAUROYL ARGINATE 83 Huntingdo
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PAPRIKA EXTRACT First draft prepare
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PAPRIKA EXTRACT 87 of capsanthin ra
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PAPRIKA EXTRACT 89 biochemical para
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PAPRIKA EXTRACT 91 Table 1. Sales o
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PAPRIKA EXTRACT 93 Table 2. Estimat
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PAPRIKA EXTRACT 95 The European Sci
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PAPRIKA EXTRACT 97 The potential di
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PAPRIKA EXTRACT 99 Hornero-Mendez,
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PAPRIKA EXTRACT 101 Appendix 1. Res
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PAPRIKA EXTRACT 103 Appendix 1. (co
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PAPRIKA EXTRACT 105 Appendix 1. (co
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108 PHOSPHOLIPASE C EXPRESSED IN PI
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PHYTOSTEROLS, PHYTOSTANOLS AND THEI
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166 POLYDIMETHYLSILOXANE (addendum)
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STEVIOL GLYCOSIDES (addendum) First
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STEVIOL GLYCOSIDES (addendum) 185 r
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STEVIOL GLYCOSIDES (addendum) 187 c
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STEVIOL GLYCOSIDES (addendum) 189 a
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STEVIOL GLYCOSIDES (addendum) 191 N
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STEVIOL GLYCOSIDES (addendum) 193 2
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STEVIOL GLYCOSIDES (addendum) 195 T
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STEVIOL GLYCOSIDES (addendum) 197 a
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STEVIOL GLYCOSIDES (addendum) 199 r
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STEVIOL GLYCOSIDES (addendum) 201 l
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STEVIOL GLYCOSIDES (addendum) 203 g
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STEVIOL GLYCOSIDES (addendum) 209 t
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STEVIOL GLYCOSIDES (addendum) 211 t
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STEVIOL GLYCOSIDES (addendum) 213 s
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STEVIOL GLYCOSIDES (addendum) 215 C
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STEVIOL GLYCOSIDES (addendum) 217 L
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STEVIOL GLYCOSIDES (addendum) 219 W
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222 SULFITES: ASSESSMENT OF DIETARY
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SAFETY EVALUATIONS OF GROUPS OF REL
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264 INTRODUCTION Figure 1. Procedur
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DIETARY EXPOSURE ASSESSMENT OF FLAV
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292 ALIPHATIC BRANCHED-CHAIN SATURA
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332 ALIPHATIC LINEAR ,-UNSATURATED
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ALKOXY-SUBSTITUTED ALLYLBENZENES PR
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ALKOXY-SUBSTITUTED ALLYLBENZENES 35
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FURAN-SUBSTITUTED ALIPHATIC HYDROCA
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Page 508 and 509: FURAN-SUBSTITUTED ALIPHATIC HYDROCA
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Page 602: ANNEXES
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602 ANNEX 1 70. Evaluation of certa
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604 ANNEX 1 108. Toxicological eval
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606 ANNEX 1 148. Residues of some v
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608 ANNEX 1 188. Safety evaluation
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610 ANNEX 2 ECG electrocardiogram E
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612 ANNEX 2 SI stimulation index SU
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614 ANNEX 3 Ms J. Baines, Food Stan
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ANNEX 4 ACCEPTABLE DAILY INTAKES, O
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ANNEX 4 619 Food additive Specifica
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ANNEX 4 621 3. FLAVOURING AGENTS 3.
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ANNEX 4 623 Flavouring agent No. Sp
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ANNEX 4 625 Flavouring agent JECFA
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ANNEX 4 627 Actual production volum
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ANNEX 4 629 Flavouring agent No. Sp
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ANNEX 5 SUMMARY OF THE SAFETY EVALU
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ANNEX 5 633 Secondary components Co
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