Safety evaluation of certain food additives - ipcs inchem

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ANNEX 4 629 Flavouring agent No. Specifications a Conclusions based on current estimated intake Dihydronootkatone 1407 S No safety concern beta-Ionyl acetate 1409 S No safety concern alpha-Isomethylionyl acetate 1410 S No safety concern 3-(l-Menthoxy)-2-methylpropane- 1,2-diol 1411 S No safety concern Bornyl butyrate 1412 S No safety concern d,l-Menthol-(±)-propylene glycol carbonate 1413 S No safety concern L-Monomenthyl glutarate 1414 S No safety concern L-Menthyl methyl ether 1415 S No safety concern p-Menthane-3,8-diol 1416 S No safety concern Taurine 1435 S No safety concern L-Arginine 1438 S No safety concern L-Lysine 1439 S No safety concern Tetrahydr<strong>of</strong>urfuryl cinnamate 1447 S No safety concern (±)-2-(5-Methyl-5vinyltetrahydr<strong>of</strong>uran-2-yl)propionaldehyde 1457 S No safety concern Ethyl 2-ethyl-3-phenylpropanoate 1475 S No safety concern 2-Oxo-3-phenylpropionic acid 1478 S No safety concern 2-Oxo-3-phenylproprionic acid sodium salt 1479 S No safety concern 2-Methyl-3-(1-oxopropoxy)- 4H-pyran-4-one 1483 S No safety concern 4-Allylphenol 1527 S No safety concern 2-Methoxy-6-(2-propenyl)phenol 1528 S No safety concern Eugenyl isovalerate 1532 S No safety concern cis-3-Hexenyl anthranilate 1538 S No safety concern Citronellyl anthranilate 1539 S No safety concern Ethyl N-methylanthranilate 1546 S No safety concern Ethyl N-ethylanthranilate 1547 S No safety concern Isobutyl N-methylanthranilate 1548 S No safety concern Methyl N-formylanthranilate 1549 S No safety concern Methyl N-acetylanthranilate 1550 S No safety concern Methyl N,N-dimethylanthranilate 1551 S No safety concern N-Benzoylanthranilic acid 1552 S No safety concern Trimethyloxazole 1553 S No safety concern 2,5-Dimethyl-4-ethyloxazole 1554 S No safety concern 2-Ethyl-4,5-dimethyloxazole 1555 S No safety concern 2-Isobutyl-4,5-dimethyloxazole 1556 S No safety concern 2-Methyl-4,5-benzo-oxazole 1557 S No safety concern 2,4-Dimethyl-3-oxazoline 1558 S No safety concern Butyl isothiocyanate 1561 S No safety concern Benzyl isothiocyanate 1562 S No safety concern Phenethyl isothiocyanate 1563 S No safety concern 4,5-Dimethyl-2-propyloxazole 1569 S No safety concern 4,5-Epoxy-(E)-2-decenal 1570 S No safety concern beta-Ionone epoxide 1571 S No safety concern Epoxyoxophorone 1573 S No safety concern
630 ANNEX 4 Flavouring agent No. Specifications a Conclusions based on current estimated intake Ethylamine 1579 S No safety concern Propylamine 1580 S No safety concern Isopropylamine 1581 S No safety concern Isobutylamine 1583 S No safety concern sec-Butylamine 1584 S No safety concern Pentylamine 1585 S No safety concern 2-Methylbutylamine 1586 S No safety concern Hexylamine 1588 S No safety concern 2-(4-Hydroxyphenyl)ethylamine 1590 S No safety concern 1-Amino-2-propanol 1591 S No safety concern Butyramide 1593 S No safety concern 1,6-Hexalactam 1594 S No safety concern 2-Isopropyl-N,2,3- 1595 S Further information is trimethylbutyramide needed N-Ethyl (E)-2,(Z)-6-nonadienamide 1596 S No safety concern N-Cyclopropyl (E)- 2,(Z)-6-nonadienamide 1597 S No safety concern N-Isobutyl (E,E)-2,4-decadienamide 1598 S No safety concern (±)-N,N-Dimethyl menthyl succinamide 1602 S No safety concern 1-Pyrroline 1603 S No safety concern 2-Acetyl-1-pyrroline 1604 S No safety concern 2-Propionylpyrroline 1605 S No safety concern Isopentylidene isopentylamine 1606 S No safety concern 2-Methylpiperidine 1608 S No safety concern Triethylamine 1611 S No safety concern Tripropylamine 1612 S No safety concern N,N-Dimethylphenethylamine 1613 S No safety concern Trimethylamine oxide 1614 S No safety concern Piperazine 1615 S No safety concern
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WHO FOOD ADDITIVES SERIES: 60 Safet
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CONTENTS Preface ..................
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PREFACE The monographs contained in
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ASPARAGINASE FROM ASPERGILLUS NIGER
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16 CALCIUM LIGNOSULFONATE (40-65) 1
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18 CALCIUM LIGNOSULFONATE (40-65) ~
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20 CALCIUM LIGNOSULFONATE (40-65) A
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22 CALCIUM LIGNOSULFONATE (40-65) c
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24 CALCIUM LIGNOSULFONATE (40-65) T
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28 CALCIUM LIGNOSULFONATE (40-65) i
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ETHYL LAUROYL ARGINATE First draft
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ETHYL LAUROYL ARGINATE 41 and Devel
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ETHYL LAUROYL ARGINATE 43 lauroyl a
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ETHYL LAUROYL ARGINATE 45 arginine.
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ETHYL LAUROYL ARGINATE 47 resulting
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ETHYL LAUROYL ARGINATE 49 Table 4.
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ETHYL LAUROYL ARGINATE 51 weight ch
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ETHYL LAUROYL ARGINATE 53 stomach l
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ETHYL LAUROYL ARGINATE 55 fibrosis
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ETHYL LAUROYL ARGINATE 57 Table 5 (
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ETHYL LAUROYL ARGINATE 59 first 4 d
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ETHYL LAUROYL ARGINATE 61 The gener
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ETHYL LAUROYL ARGINATE 63 treatment
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ETHYL LAUROYL ARGINATE 65 gestation
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ETHYL LAUROYL ARGINATE 67 Body weig
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ETHYL LAUROYL ARGINATE 69 Table 6.
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ETHYL LAUROYL ARGINATE 77 About 99%
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ETHYL LAUROYL ARGINATE 79 concentra
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ETHYL LAUROYL ARGINATE 81 theoretic
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ETHYL LAUROYL ARGINATE 83 Huntingdo
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PAPRIKA EXTRACT First draft prepare
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PAPRIKA EXTRACT 87 of capsanthin ra
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PAPRIKA EXTRACT 89 biochemical para
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PAPRIKA EXTRACT 91 Table 1. Sales o
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PAPRIKA EXTRACT 93 Table 2. Estimat
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PAPRIKA EXTRACT 95 The European Sci
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PAPRIKA EXTRACT 97 The potential di
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PAPRIKA EXTRACT 99 Hornero-Mendez,
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PAPRIKA EXTRACT 101 Appendix 1. Res
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PAPRIKA EXTRACT 103 Appendix 1. (co
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PAPRIKA EXTRACT 105 Appendix 1. (co
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108 PHOSPHOLIPASE C EXPRESSED IN PI
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PHYTOSTEROLS, PHYTOSTANOLS AND THEI
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166 POLYDIMETHYLSILOXANE (addendum)
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STEVIOL GLYCOSIDES (addendum) First
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STEVIOL GLYCOSIDES (addendum) 185 r
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STEVIOL GLYCOSIDES (addendum) 187 c
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STEVIOL GLYCOSIDES (addendum) 189 a
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STEVIOL GLYCOSIDES (addendum) 191 N
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STEVIOL GLYCOSIDES (addendum) 193 2
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STEVIOL GLYCOSIDES (addendum) 195 T
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STEVIOL GLYCOSIDES (addendum) 197 a
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STEVIOL GLYCOSIDES (addendum) 199 r
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STEVIOL GLYCOSIDES (addendum) 201 l
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STEVIOL GLYCOSIDES (addendum) 203 g
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STEVIOL GLYCOSIDES (addendum) 209 t
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STEVIOL GLYCOSIDES (addendum) 211 t
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STEVIOL GLYCOSIDES (addendum) 213 s
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STEVIOL GLYCOSIDES (addendum) 215 C
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STEVIOL GLYCOSIDES (addendum) 217 L
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STEVIOL GLYCOSIDES (addendum) 219 W
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222 SULFITES: ASSESSMENT OF DIETARY
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SAFETY EVALUATIONS OF GROUPS OF REL
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264 INTRODUCTION Figure 1. Procedur
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DIETARY EXPOSURE ASSESSMENT OF FLAV
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292 ALIPHATIC BRANCHED-CHAIN SATURA
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332 ALIPHATIC LINEAR ,-UNSATURATED
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ALKOXY-SUBSTITUTED ALLYLBENZENES PR
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ALKOXY-SUBSTITUTED ALLYLBENZENES 35
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FURAN-SUBSTITUTED ALIPHATIC HYDROCA
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HYDROXY- AND ALKOXY-SUBSTITUTED BEN
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MISCELLANEOUS NITROGEN-CONTAINING S
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Page 587 and 588: 580 SUBSTANCES STRUCTURALLY RELATED
Page 602: ANNEXES
Page 605 and 606: 598 ANNEX 1 10. Specifications for
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Page 615 and 616: 608 ANNEX 1 188. Safety evaluation
Page 617 and 618: 610 ANNEX 2 ECG electrocardiogram E
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Page 624 and 625: ANNEX 4 ACCEPTABLE DAILY INTAKES, O
Page 626 and 627: ANNEX 4 619 Food additive Specifica
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Page 630 and 631: ANNEX 4 623 Flavouring agent No. Sp
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Page 638 and 639: ANNEX 5 SUMMARY OF THE SAFETY EVALU
Page 640 and 641: ANNEX 5 633 Secondary components Co
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