Safety evaluation of certain food additives - ipcs inchem

322 ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS
Table 5 (contd)
No. Flavouring agent End-point Test object Concentration Results Reference
Positive k Yang et al. (2003)
CHO cells 106 –103 (v/v), S9 (~1–1000 μg/mlb,l )
Sister chromatid
exchange
1834 Methyl 2-methyl-
2-propenoate
Negative Anderson et al. (1979)
Cell transformation BHK21/C13 cells 0.000 001–0.01 mol/l
(~0.1–1000 μg/mld )
1834 Methyl 2-methyl-
2-propenoate
In vivo
Negative ICI (1976b)
Male mice 400, 4000 or 40 000
mg/m3 via inhalation
(6 h/day, 5 days)
1834 Methyl 2-methyl- Dominant lethal
2-propenoate mutation
Negative Hachitani et al. (1981)
Mouse bone marrow 1 × 4500 mg/kg bw,
intraperitoneally; 4 × 1100
mg/kg bw, intraperitoneally
Micronuclei
induction
1834 Methyl 2-methyl-
2-propenoate
Negative g Hachitani et al. (1982)
Mouse (ddY) bone marrow 1 × 1.13, 2.26 or 4.52 g/kg
bw, oral gavage; 4 × 1.13 g/kg
bw, oral gavage
Micronuclei
induction
1834 Methyl 2-methyl-
2-propenoate
Negative Miyagawa et al. (1995)
1 × 1000 or 2000 mg/kg bw,
oral gavage
Mouse (B6C3F1)
hepatocytes
Replicative DNA
synthesis
1834 Methyl 2-methyl-
2-propenoate
Humans (38 workers) 3.7–290 mg/m 3 via inhalation o Negative Seiji et al. (1994)
Chromosomal
aberration
1834 Methyl 2-methyl-
2-propenoate
Positive Fedyukovich &
Egorova (1991)
Rat bone marrow 1 × 1300 mg/kg bw, intraperitoneally;
650 mg/kg bw,
2× per week, up to 8 weeks,
intraperitoneally
Chromosomal
aberration
1834 Methyl 2-methyl-
2-propenoate