Safety evaluation of certain food additives - ipcs inchem

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ANNEX 2 ABBREVIATIONS USED IN THE MONOGRAPHS 8-OH-dG 8-hydroxy-2-deoxyguanosine ABCG5/8 ATP-binding cassette sterol efflux transporter protein ACC acetyl-coenzyme A carboxylase ACF aberrant crypt foci ADI acceptable daily intake AFEXPO Association for Manufacturers and Exporters of Pimentos and Derivatives AgNOR silver-stained nucleolar organizer region Ah aryl hydrocarbon ALP alkaline phosphatase ALT alanine aminotransferase ANOVA analysis of variance AOAC Association of Official Analytical Chemists AOM azoxymethane AOX1 alcohol oxidase 1 ASPU asparaginase unit AST aspartate aminotransferase ATDS Australian Total Diet Study ATP adenosine triphosphate AUC area under the concentration–time curve BMI body mass index bw body weight Cmax maximum concentration CCCF Codex Committee on Contaminants in Food CCFA Codex Committee on Food Additives CCFAC Codex Committee on Food Additives and Contaminants CFSAN Center for Food Safety and Applied Nutrition CHD coronary heart disease CHO Chinese hamster ovary Chol cholesterol CI confidence interval CoA coenzyme A CYP cytochrome P450 Da dalton DAFNE Dose Adjustment for Normal Eating dGMP deoxyguanosine monophosphate DG SANCO Directorate General for Health and Consumer Affairs DNA deoxyribonucleic acid DRE dioxin-responsive enhancer dUTP 2-deoxyuridine-5-triphosphate EC Enzyme Commission EC50 median effective concentration - 609 -
610 ANNEX 2 ECG electrocardiogram EFFA European Flavour and Fragrance Association EFSA European Food Safety Authority EPIC European Prospective Investigation of Cancer EROD 7-ethoxyresorufin O-deethylation EU European Union FAO Food and Agriculture Organization of the United Nations FARRP Food Allergy Research and Resource Program FDA Food and Drug Administration (USA) FEMA Flavor and Extract Manufacturers Association FOB functional observational battery GC gas chromatography GEMS/Food Global Environment Monitoring System – Food Contamination Monitoring and Assessment Programme GGT gamma-glutamyltransferase GLP Good Laboratory Practice GMP Good Manufacturing Practice GPT glutamic–pyruvic transaminase GRAS Generally Recognized as Safe GSFA General Standard for Food Additives GSH glutathione GST glutathione S-transferase HbA1c glycated haemoglobin HDL high-density lipoprotein Hex-PdG 1-N2-propanodeoxyguanosine HPLC high-performance liquid chromatography IC50 median inhibitory concentration ICH International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use IL interleukin INS International Numbering System IOFI International Organization of the Flavour Industry IU International Unit JFFMA Japan Flavor & Fragrance Materials Association k rate constant Km Michaelis-Menten constant LASA Longitudinal Aging Study Amsterdam LC liquid chromatography LC50 median lethal concentration LD50 median lethal dose LDH lactate dehydrogenase LDL low-density lipoprotein LHP lipid hydroperoxide LOAEL lowest-observed-adverse-effect level
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WHO FOOD ADDITIVES SERIES: 60 Safet
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CONTENTS Preface ..................
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PREFACE The monographs contained in
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ASPARAGINASE FROM ASPERGILLUS NIGER
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16 CALCIUM LIGNOSULFONATE (40-65) 1
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18 CALCIUM LIGNOSULFONATE (40-65) ~
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20 CALCIUM LIGNOSULFONATE (40-65) A
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22 CALCIUM LIGNOSULFONATE (40-65) c
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24 CALCIUM LIGNOSULFONATE (40-65) T
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28 CALCIUM LIGNOSULFONATE (40-65) i
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ETHYL LAUROYL ARGINATE First draft
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ETHYL LAUROYL ARGINATE 41 and Devel
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ETHYL LAUROYL ARGINATE 43 lauroyl a
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ETHYL LAUROYL ARGINATE 45 arginine.
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ETHYL LAUROYL ARGINATE 47 resulting
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ETHYL LAUROYL ARGINATE 49 Table 4.
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ETHYL LAUROYL ARGINATE 51 weight ch
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ETHYL LAUROYL ARGINATE 53 stomach l
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ETHYL LAUROYL ARGINATE 55 fibrosis
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ETHYL LAUROYL ARGINATE 57 Table 5 (
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ETHYL LAUROYL ARGINATE 59 first 4 d
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ETHYL LAUROYL ARGINATE 61 The gener
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ETHYL LAUROYL ARGINATE 63 treatment
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ETHYL LAUROYL ARGINATE 65 gestation
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ETHYL LAUROYL ARGINATE 67 Body weig
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ETHYL LAUROYL ARGINATE 69 Table 6.
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ETHYL LAUROYL ARGINATE 77 About 99%
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ETHYL LAUROYL ARGINATE 79 concentra
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ETHYL LAUROYL ARGINATE 81 theoretic
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ETHYL LAUROYL ARGINATE 83 Huntingdo
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PAPRIKA EXTRACT First draft prepare
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PAPRIKA EXTRACT 87 of capsanthin ra
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PAPRIKA EXTRACT 89 biochemical para
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PAPRIKA EXTRACT 91 Table 1. Sales o
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PAPRIKA EXTRACT 93 Table 2. Estimat
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PAPRIKA EXTRACT 95 The European Sci
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PAPRIKA EXTRACT 97 The potential di
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PAPRIKA EXTRACT 99 Hornero-Mendez,
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PAPRIKA EXTRACT 101 Appendix 1. Res
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PAPRIKA EXTRACT 103 Appendix 1. (co
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PAPRIKA EXTRACT 105 Appendix 1. (co
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108 PHOSPHOLIPASE C EXPRESSED IN PI
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PHYTOSTEROLS, PHYTOSTANOLS AND THEI
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166 POLYDIMETHYLSILOXANE (addendum)
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STEVIOL GLYCOSIDES (addendum) First
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STEVIOL GLYCOSIDES (addendum) 185 r
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STEVIOL GLYCOSIDES (addendum) 187 c
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STEVIOL GLYCOSIDES (addendum) 189 a
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STEVIOL GLYCOSIDES (addendum) 191 N
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STEVIOL GLYCOSIDES (addendum) 193 2
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STEVIOL GLYCOSIDES (addendum) 195 T
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STEVIOL GLYCOSIDES (addendum) 197 a
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STEVIOL GLYCOSIDES (addendum) 199 r
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STEVIOL GLYCOSIDES (addendum) 201 l
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STEVIOL GLYCOSIDES (addendum) 203 g
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STEVIOL GLYCOSIDES (addendum) 209 t
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STEVIOL GLYCOSIDES (addendum) 211 t
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STEVIOL GLYCOSIDES (addendum) 213 s
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STEVIOL GLYCOSIDES (addendum) 215 C
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STEVIOL GLYCOSIDES (addendum) 217 L
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STEVIOL GLYCOSIDES (addendum) 219 W
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222 SULFITES: ASSESSMENT OF DIETARY
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SAFETY EVALUATIONS OF GROUPS OF REL
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264 INTRODUCTION Figure 1. Procedur
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DIETARY EXPOSURE ASSESSMENT OF FLAV
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292 ALIPHATIC BRANCHED-CHAIN SATURA
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332 ALIPHATIC LINEAR ,-UNSATURATED
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ALKOXY-SUBSTITUTED ALLYLBENZENES PR
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FURAN-SUBSTITUTED ALIPHATIC HYDROCA
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HYDROXY- AND ALKOXY-SUBSTITUTED BEN
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MISCELLANEOUS NITROGEN-CONTAINING S
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Page 566 and 567: MISCELLANEOUS NITROGEN-CONTAINING S
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Page 587 and 588: 580 SUBSTANCES STRUCTURALLY RELATED
Page 602: ANNEXES
Page 605 and 606: 598 ANNEX 1 10. Specifications for
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Page 619 and 620: 612 ANNEX 2 SI stimulation index SU
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Page 624 and 625: ANNEX 4 ACCEPTABLE DAILY INTAKES, O
Page 626 and 627: ANNEX 4 619 Food additive Specifica
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Page 630 and 631: ANNEX 4 623 Flavouring agent No. Sp
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Page 638 and 639: ANNEX 5 SUMMARY OF THE SAFETY EVALU
Page 640 and 641: ANNEX 5 633 Secondary components Co
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