Safety evaluation of certain food additives - ipcs inchem

554 MISCELLANEOUS NITROGEN-CONTAINING SUBSTANCES (addendum)
Table 1 (contd)
Conclusion based
on current
estimated intake
Comments
on predicted
metabolism
Step B4
Adequate margin of safety for
the flavouring agent or related substance?
No. CAS No. and structure Step B3d Does intake exceed
the threshold for
human intake?
Flavouring
agent
See note 1 No safety concern
Yes. The NOELe of 12 mg/kg bw per day
for the related substance allyl
isothiocyanate (No. 1560) (National
Toxicology Program, 1982) is >17 000
times the estimated daily intake of
5-hexenyl isothiocyanate when used as a
flavouring agent.
No
Europe: ND
USA: ND
Japan: 40
1894 49776-81-0
5-Hexenyl
isothiocyanate
N C S
See note 1 No safety concern
Yes. The NOEL of 30 mg/kg bw per day for
the related substance 3-(methylthio)propyl
isothiocyanate (No. 1564) (Harper et al.,
1961) is 15 million times the estimated daily
intake of 5-(methylthio)pentyl
isothiocyanate when used as a flavouring
agent.
No
Europe: ND
USA: ND
Japan: 0.1
1896 4430-42-6
5-(Methylthio)pentyl
isothiocyanate
S
N C S
See note 1 No safety concern
Yes. The NOEL of 30 mg/kg bw per day for
the related substance 3-(methylthio)propyl
isothiocyanate (No. 1564) (Harper et al.,
1961) is 600 000 times the estimated daily
intake of 6-(methylthio)hexyl
isothiocyanate when used as a flavouring
agent.
No
Europe: ND
USA: ND
Japan: 3
1897 4430-39-1
S
6-(Methylthio)hexyl
isothiocyanate
N C S